ARTIFICIAL INTELLIGENCE AND EXPLAINABLE AI IN MEDICINE: DISEASE PREDICTION AND EFFECTIVENESS IN CLINICAL DECISION-MAKING
This article examines artificial intelligence (AI), particularly explainable artificial intelligence (XAI), and its application in disease
prediction in medicine. It discusses the operating principles of classification models, explanation methods using SHAP and LIME,
effectiveness in clinical decision-making, and practical limitations associated with XAI outcomes. The paper reviews AI systems
based on electronic health records (EHR) and medical imaging, focusing on their accuracy, sensitivity, and the need for
transparency, as well as methods for enhancing clinical reliability through visualization of model results.
1. Сalih-Sumner, A. M., Raisi-Estabragh, Z., Galazzo, I. B. и др. A Perspective on Explainable Artificial Intelligence Methods:
SHAP and LIME. Advanced Intelligent Systems, 2024. DOI:10.1002/aisy.202400304. qmro.qmul.ac.uk
2. Vimbi, V., Shaffi, N., Mahmud, M. и др. Interpreting artificial intelligence models: a systematic review on the application
of LIME and SHAP in Alzheimer’s disease detection. Brain Informatics, 2024, т. 11, ст. 10. DOI:10.1186/s40708-024-
00222-1. SpringerOpen+1
3. Adeniran, A. A., Onebunne, A. P., Paul, W. Explainable AI (XAI) in Healthcare: Enhancing trust and transparency in critical
decision-making. World Journal of Advanced Research and Reviews, 2024, 23(03), 2647–2658.
DOI:10.30574/wjarr.2024.23.3.2936. wjarr.com
4. Singh, B. Explainable AI in Healthcare: A Review of Interpretability Techniques and Applications. International Journal of
Sustainable Development in Computer Science Engineering, 2020+. journals.threws.com
5. Saidov, A. D., Sharipov, D. K. The Importance of Explainability in Medical AI and Predictor Reduction in Cardiovascular
Risk Assessment. Digital Transformation and Artificial Intelligence, 2025, 3(1), 191–195. dtai.tsue.uz
6. Zribi, M., Zaier, F., Aounallah-Skhiri, H. Is explainability the missing link in artificial intelligence-based diabetes prediction?
European Journal of Public Health, 2025, 35(Suppl_4). DOI:10.1093/eurpub/ckaf161.1294. OUP Academic
7. Sharma, P. Optimizing Healthcare Decisions Using Explainable AI for Enhanced Predictions. International Journal of
Computations, Information and Manufacturing, 2024, 4(1). journals.gaftim.com
8. (systematic review) The role of explainable artificial intelligence in disease prediction: a systematic literature review and
future research directions. BMC Medical Informatics and Decision Making, 2025, 25:110. BioMed Central
9. Vaddepally, D. Explainable AI (XAI) Techniques in Mobile Environments. International Journal on Science and Technology
(IJSAT), 2025. ijsat.org
10. Elias, F., Reza, M. S., Mahmud, M. Z., Islam, S. Machine Learning Meets Transparency in Osteoporosis Risk Assessment:
A Comparative Study of ML and Explainability Analysis. arxiv preprint, 2025
11. AXMADIYEV, N. (2025). PHILOSOPHICAL AND METHODOLOGICAL FOUNDATIONS OF SOCIETY DEVELOPMENT. «ACTA NUUz», 1(1.12), 73–75. Retrieved from https://journalsnuu.uz/index.php/actanuuz/article/view/10257
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