"THE FUNCTION OF GENES RESPONSIBLE FOR THE BIOTRANSFORMATION OF XENOBIOTICS IN THE PROGRESSION OF TUMORS IN ACUTE LEUKEMIA” (LITERATURE REVIEW)

Oncogenesis, gene network, suppressor genes, xenobiotic biotransformation, modifier genes, MDR1 gene, C3435T gene polymorphism, acute leukemia

Authors

  • Зульфия САБИТОВА Магистрантка Ташкентского международного химического университета, Uzbekistan
  • Кодиржон БОБОЕВ, Гематологический республиканский специализированный научно-практический медицинский центр. Д.т.н., профессор, Uzbekistan
  • Полвонжин ГАНИЖОНОВ Ф.Ж.С.Т.И Доцент кафедры физиологии, Uzbekistan

Relevance: The significance of the problem lies in the fact that oncogenesis, like any pathogenetic process, is formed due to the activity of systemic genes in the gene network. Oncogenes and suppressor genes play the main role in this network, while other genes, including those involved in the biotransformation of xenobiotics, function as modifiers of the main genes