REDUCTION OF ANTIOXIDANT SYSTEM ACTIVITY IN HYPOTHYROIDISM AND ITS CORRECTION WITH POLIPHENOLS OF SUMAC PLANT
In recent years, the increase of endocrine diseases among the population is one of the serious problems of the world medicine. In this regard, one of the urgent problems of endocrinology is the problem of thyroid gland diseases, which consists in studying the mechanisms of action of thyroid hormones in the body, their biosynthesis and their metabolism, and developing new medicinal preparations. Biologically active compounds extracted from plants are of great importance in the treatment of various pathologies and in the creation of effective pharmacological preparations. In this article, the effect of hypothyroidism on antioxidant enzymes and the correcting effect of poliphenols isolated from sumac plants on this process will be highlighted.
Agati G., Azzarello E., Pollastri S., Tattini M. Flavonoids as antioxidants in plants: Location and functional significance. // Plant Sci. 2012, 196, 67–76 p.
C. Brunetti, M. Di Ferdinando, A. Fini, S. Pollastri and M.Tattini, Flavonoids as Antioxidants and Developmental Regulators: Relative Significance in Plants and Humans. // International Journal of Molecular Sciences – 2013, 14(2): 3540-3555. doi: 10.3390/ijms14023540
Alan Miller, Antioksidant flavonoids: Structure, function, and clinical usage. 2016.
Rahideh ST, Shidfar F, Khandozi N, Rajab A, Hosseini SP, Mirtaher SM: The effect of sumac (Rhus coriaria L.) powder on insulin resistance, malondialdehyde, high sensitive C-reactive protein and paraoxonase 1 activity in type 2 diabetic patients. // J Res Med Sci 2014;19:933–938.
Maleśev D, Kunti V. Investigation of metal-flavonoid chelates and the determination of flavonoids via metalflavonoid complexing reactions. // J Serb Chem Soc. 2007;72(10):921-39.)
Said, O.; Khalil, K.; Fulder, S.; Azaizeh, H. Ethnopharmacological Survey of Medicinal Herbs in Israel, the Golan Heights and the West Bank Region. J. // Ethnopharmacol. 2002, 83, 251–265. [Google Scholar] [CrossRef]
Abu-Reidah, I.M.; Jamous, R.M.; Ali-Shtayeh, M.S. Phytochemistry, Pharmacological Properties and Industrial Applications of Rhus coriaria L. (Sumac). // JJBS 2014, 7, 233–244. [Google Scholar] [CrossRef][Green Version]
Kizil, S.; Turk, M. Microelement Contents and Fatty Acid Compositions of Rhus coriaria L. and Pistacia Terebinthus, L. Fruits Spread Commonly in the South Eastern Anatolia Region of Turkey. // Nat. Prod. Res. 2010, 24, 92–98. [Google Scholar] [CrossRef] [PubMed]
Козлов В.Н. Тиреоидная трансформация при моделировании эндемического эффекта у белых крыс в эксперименте // Сибирский медицинский журнал. 2006.-№ 5. С 27-30.
B.X.Shagazatova. Endokrinologiya: darslik. Toshkent, “Ijod-print” 2021-yil, 464 bet. 11. D.Beslo., N.Golubic., V.Rastija., D.Agic. Antioxidant activity, metabolism, and bioavailability of poliphenols in the diet of animals. //Antioxidants 2023, 12(6), 1141. https://doi.org/10.3390/antiox12061141.
Cadet, J; Wagner, J.R. DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation. Cold spring Harb. Perspect Biol. 2013,5, a012559.
Z.Salimi., A.Eskandary., R.Headari., V.Nejati., M.Moradi., Z.Kalhori. Antioxidant effect of aqueous extract of sumac (Rhus coriaria L.) in the alloxan-induced diabetic rats. // Indian J Physiol Pharmacol. 2015; 59(1):87-93.
https://yuz.uz/uz/news/ozbekiston
Kamail Al-sowdani. Effect of deficiency thyroid hormone on superoxide dismutase activity enzyme and their releted metals in hypothyroid patients in Iraq. // J.Thi-Qar Sci. 2013 Vol.3 (4) ISSN 19918690
.jpg)
1.png)
