OʻTKIR YOG’LI GEPATOZDA METABOLIK JARAYONLAR BUZILISHLARINI KORREKSIYALASHDA SUPRAMOLEKULYAR KOMPLEKS BIRIKMA TA’SIRINI ANIQLASH
In the model of acute hepatosis, the activity of the enzymes ALT, AST, levels of total protein, glucose, triglycerides, and cholesterol in the blood serum, as well as methods of their restoration using a new supramolecular complex were studied. Our results showed that alcohol-induced fatty hepatosis led to increased ALT and AST activity, as well as elevated total protein, glucose, triglycerides, and cholesterol levels in the serum. These changes were effectively addressed by a new supramolecular complex derived from local plants.
1. John B.W., Steven M., Suthat L., Jessica H., Sebastian M. et.al. Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis // Alcohol. – 2018. – V.66. – P.1-7.
2. Диковский А.В., Закирова С.А. Фармацевтическая композиция для лечения гиперлипидимии. Ru Патент. 2019. Бюл. № 10.
3. Pastorino G., Cornara L., Soares S. Liquorice (Glycyrrhizaglabra): A phytochemical and phar macological review // Phytotherapy Research. -2018. 32. –P. 2323–2339.
4. Владислав О.Д. Эффективность комплекса лекарственных препаратов при экспериментальной жировой дистрофии печени белых крыс. Ветеринарный врач. 2022. 3. -С. 41-45. DOI 10.33632/1998-698Х.2021_41_45.
5. Arafa A.F., Foda D.S., Mahmoud A.H., Metwally N.S., Farrag A.R.H. Bombax ceiba flowers extract ameliorates hepatosteatosis induced by ethanol and relatively moderate fat diet in rats // Toxicology reports. – 2019. – V.6. – P. 401408. www.elsevier.com/locate/toxrep.
6. Li X.X., Zhao Y., Huang L.X., Xu H.X., Liu X.Y., Yang J.J., Zhang P.J., Zhang Y.H. Effects of smoking and alcohol consumption on lipid profile in male adults in northwest rural China // Public health. –2018. –V.157. –P.7-13. www.elsevier.com/puhe.
7. Abdullayeva M.I., Inoyatova F.Kh., Narbutayeva D.A., Siddiqiv D. Changes in biochemical indexes of rats blood during chronic ethanol poisoning and treatment them with herbal preparations // International Journal of Scientific and Technology research. – 2020. – Vol.9. – Issue.3. – P.701-709.
8. Samah A.E., Shaffie N.M., Omer E.A. The protection effect of Thymus vulgaris leaves alcoholic extract against hepatotoxicity of alcohol in rats // Asian Pacific Journal of Tropical Medicine. –2017. –P.10(4). –P.361-371. http://ees.elsevier.com/apjtm.
9. Kim M.K., Shin J., Kweon S.S., Shin D.H., Lee Y.H., Chun B.Y., Choi B.Y.. Harmful and beneficial relationships between alcohol consumption and subclinical atherosclerosis. Nutrition, Metabolism & Cardiovascular Diseas. –2014. – V.24. – P.767-776. www.elsevier.com/locate/nmcd.
10. Xue Y., Li X., Tian Y., Huang X., Zhang L., Li J., Hou H., Dong P., Wang J. Salmon sperm DNA prevents acute liver injury by regulating alcohol-induced steatosis and restores chronic hepatosis via alleviating inflammation and apoptosis // J Food Biochem. – 2022. –V.46(10). e14346. doi: 10.1111/jfbc.14346.
11. Wang P., Zheng X., Du R., Xu J., Li J., Zhang H., Liang X., Liang H. Astaxanthin Protects against Alcoholic Liver Injury via Regulating Mitochondrial Redox Balance and Calcium Homeostasis // J Agric Food Chem. -2023. –V.71(49). – P.19531-19550. doi: 10.1021/acs.jafc.3c05529.
12. Geng X., Du X., Wang W., Zhang C., Liu X., Qu Y., Zhao M., Li W., Zhang M., Tu K., Li YQ. Confined Cascade Metabolic Reprogramming Nanoreactor for Targeted Alcohol Detoxification and Alcoholic Liver Injury Management // ACS Nano. -2023. –V.17(8). –P.7443-7455. doi: 10.1021/acsnano.2c12075.
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