SYNTHESIS OF ACETYLENE DIOLS BASED ON THE GRIGNARD-IOTSICH REAGENT
Acetylene diols were synthesized by alkylation of butadione-2,3, pentadione-2,4, 3-methylpentadione-2,4, hexadione-2,5, 1(thiophenyl-2)pentadione-1,4 and 4,4,4-trifluoro-1-(thiophenyl-2)butadione-1,3 ketones based on the Grignard reagent. The effect of the aprotic solvents DEE and THF on the product yield and the reaction duration on the product yield were studied. It was found that the solvent THF and the AD product synthesized in 240 minutes gave a high yield
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