SYNTHESIS OF SCHIFF BASES 5-ARYL-2-AMINO-1,3,4-THIADIAZOLES
Optimal conditions for reactions of 5-(phenyl, 2,4-dichlorophenyl)-2-amino-1,3,4-thiadiazoles with aromatic aldehydes were found. The structure of the synthesized 5-(R-phenyl)-2-amino1,3,4-thiadiazoles and azomethine (Schiff bases) derivatives was confirmed by spectral (IR, 1H NMR, 13C NMR) methods, the physicochemical constants of the substances were determined.
1. Sharma B., Verma A., Prajapati S. and Sharma U.K. Synthetic Methods, Chemistry and the Anticonvulsant Activity of Thiadiazoles // Int. J. Medicinal Chemistry. 2013. -P. 1-16.
2. Serban G. Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections // Molecules. 2020. -Vol. 25. -№ 4. - R. 942.
3. Hu Y., Li C.-Y., Wang X.-M., Yang Y.-H. & Zhu H.-L. 1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials // Chem.&Chem.Rev. 2014. -Vol. 114. -№ 10, - R. 5572-5610. 4. Ahmed A. J. Pharmacological activity of 1,3,4-thiadiazole derivatives and its complexes: Areview // Int. Res. J. Pharm. 2018.-Vol. 9. -№ 10, -P. 4-15.
5. Janowska S., Paneth A. and Wujec M. Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives-A Review // Molecules. 2020. -Vol. 25, -P. 1-41.
6. Othman A. Adil, Kihel Mebrouk, Amara Sarah. 1,3,4-Oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole derivatives as potential antibacterial agents // Arabian Journal of Chemistry. 2014. -P. 1-29.
7. Ramalingam D. J., Chandy V. 1,3,4-Thiadiazoles: An Overview // Curr. Res. Bioorg. Org. Chem. 2018. -Vol. 18. -P. 1-9.
8. Kamal M. Dawood & Thoraya A. Farghaly. Thiadiazole inhibitors: a patent review // Expert Opinion on Therapeutic Patents. 2016. –P. 1-81.
9. Barbosa G. A. D., de Aguiar A.P. Synthesis of 1,3,4-Thiadiazole Derivatives and Microbiological Activities: A Review // Rev. Virtual Quim. 2019. –Vol. 11. -№ 3. –P. 806-848.
10. Jablonowski D. Nicolai, Linden Andreas, Köppchen Stephan, Thiele Björn, Hofmann Diana, Mittelstaedt Werner, Pütz Thomas, Burauel Peter. Long-term persistence of various 14C-labeled pesticides in soils // Environmental Pollution. 2012. – Vol. 168. –P. 29-36.
11. Losanitch S. M. Decomposition of dithiocarbazinates // J. Chem. Soc. 1922. –Vol. 121. 2542.
12. Toshmurodov T.T., Ziyaev A.A., Elmuradov B.Z., Ismailova D.S., Kurbanova E.R. Highly Selective Synthesis and Fungicidal Activity of the Novel 2-Alkylthio-5-Amino-1,3,4-Thiadiazoles // Journal of Chemistry and Chemical Sciences. 2016. –Vol. 6. -№ 3. –P. 199-204. 13. Makhmudov U.S., Toshmurodov T.T., Ziyaev A.A., Turgunov K.K., Elmuradov B.Zh., Tashkhodjaev B. Structural Investigation of 5-amino-1,3,4-thiadiazoles containing different alkyl groups // Journal of Multidisciplinary Engineering Science and Technology (JMEST). 2017. –Vol. 4. -№ 1. –P. 6488-6490.
14. Тошмуродов Т.Т., Зияев А.А. Синтез новых тиазолидин-4-он производных 2-алкилтио-5-амино-1,3,4-тиадиазолов // Материалы Международной научной конференции студентов, аспирантов и молодых учёных «Ломоносов-2021» Москва. 12-23 апреля 2021г. С. 733.
15. Toshmurodov T.T. Ziyaev A.A. Synthesis of new (5-alkylsulphanyl-[1,3,4]thiadiazol-2-yl)-(3,4-diphenyl-3H-thiazol-2ylidene)amines // 14th Inter-national Symposium on the Chemistry of Natural Compounds, October 7-8, 2021 Tashkent, Uzbekistan. -P. 69. 16. Abdimuratova Z.E., Toshmurodov T.T., Boboev B.N., Ziyaev A.A. 2-Amino-5-aril-1,3,4-tiadiazol va 2-alkiltio-5-amino1,3,4-tiadiazol hosilalari sintezi // Zamonaviy organik kimyo: yutuqlar, muammolar, echimlar. 2024, 20-21 sentyabr, 52-53 b.
17. Georgeta Serban, Oana Stanasel, Eugenia Serban, Sanda Bota 2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents // Drug Design, Development and Therapy. 2018. Vol.12. P. 1545-1566. 18. Ahmed H. Shamroukh, Mohamed I. Hegab A Review on Synthesis, Therapeutic, and Computational Studies of Substituted 1,3,4 Thiadiazole Derivatives // Egypt. J. Chem. 2020. Vol. 63., No. 11. P. 4387-4408.
19. Vinit Raj, Amit Rai, Sudipta Saha Human Cancer Cell Line Based Approach of 1,3,4-thiadiazole and its Fused Ring: A Comprehensive Review // Anti-Cancer Agents in Medicinal Chemistry. 2017. Vol. 17. P. 500-523
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