THEORETICAL STUDY AND COMPARATIVE COMPARISON OF BIOLOGICAL ACTIVITIES OF 1-(4-BROMOPHENOXY)PROPYNE-2 AND ITS DIMERIZATION PRODUCT - 1,6-BIS(4-BROMOPHENOXY)HEXADIINE-2,4
Keywords:
pharmacological activity, pharmacological inactivity, Pass (Prediction of activity spectra for substances), biological activity, 1-(4-bromophenoxy)propyne-2, inhibitor, 1,6-bis(4-bromophenoxy)hexadiine-2,4
Abstract
In this article, the biological activities of 1-(4-bromophenoxy)propyn-2 and its dimer - 1,6-bis(4-bromophenoxy)hexadiin-2,4 were determined by PASS (online) program, as well as studied by comparative analysis.
References
vAbatov M.A. Theoretical study of the biological activity of 1,6-bis(4-bromophenoxy)hexa-2,4-diine . // European Journal of Interdisciplinary Research and Development. –2024. –V.31. –P. 34-38.
2. Abatov M.A., Abdugafurov I.A., Mamajonov J.SH. Pass online dasturi yordamida 1,6-bis(4-bromofenoksi)geksa-2,4-diin ning biologik faolligini nazariy o‘rganish. // O‘zbekiston Milliy universitetining kimyo fakulteti “Barqaror rivojlanishda kimyo faning roli” mavzusidagi professor-o‘qituvchilar, yosh olimlar, magistrantlar va iqtidorli talabalar ishtirokidagi ilmiy-amaliy anjumani to‘plami. –2024. –P. 115-116.
3. Mardonova U.O‘., Shokirov M.T., Toshov H.S. Di (2-aminotiazol)gossipolning biologik faolligini pass (online) dasturida tekshirish. // Eurasian journal of academic research. –2021. –V.1. –I.8. –P.268-270.
4. https://www.way2drug.com/PassOnline.
5. Takahashi I., Ojima N., Ogura K., Seto S. “Purification characterization of dimethylallyl pyrophosphate: aspulvinone dimethylallyltransferase from Aspergillus terreus”. // Biochemistry. –1978. –V.17. № 13. –P. 2696–2702.
6. Catherine Tomaro-Duchesneau, Shyamali S., Meenakshi M., Coussa-Charley M., Imen K., Mitchell L.J., Alain L., Satya P. “Probiotic Ferulic Acid Esterase Active Lactobacillus fermentum NCIMB 5221 APA Microcapsules for Oral Delivery: Preparation and in Vitro Characterization”. // Pharmaceuticals. –2012. –V.5. № 2. –P. 236–248. 7. Turzynski A., Mentlein R. “Prolyl aminopeptidase from rat brain and kidney. Action on peptides and identification as leucyl aminopeptidase”. // European Journal of Biochemistry. –1990. –V.190. № 3. –P. 509-515.
8. https://www.ncbi.nlm.nih.gov/books/NBK500003. 9. Kestelman P., Trussell J. “Efficacy of the simultaneous use of condoms and spermicides”. // Family Planning Perspectives. –1991. –V.23. № 5. –P. 226-227-232. 10. Tryon W.W. Activity Measurement in Psychology and Medicine. –New York. Springer Publishing / Plenum Press. –1991. –P. 260.
2. Abatov M.A., Abdugafurov I.A., Mamajonov J.SH. Pass online dasturi yordamida 1,6-bis(4-bromofenoksi)geksa-2,4-diin ning biologik faolligini nazariy o‘rganish. // O‘zbekiston Milliy universitetining kimyo fakulteti “Barqaror rivojlanishda kimyo faning roli” mavzusidagi professor-o‘qituvchilar, yosh olimlar, magistrantlar va iqtidorli talabalar ishtirokidagi ilmiy-amaliy anjumani to‘plami. –2024. –P. 115-116.
3. Mardonova U.O‘., Shokirov M.T., Toshov H.S. Di (2-aminotiazol)gossipolning biologik faolligini pass (online) dasturida tekshirish. // Eurasian journal of academic research. –2021. –V.1. –I.8. –P.268-270.
4. https://www.way2drug.com/PassOnline.
5. Takahashi I., Ojima N., Ogura K., Seto S. “Purification characterization of dimethylallyl pyrophosphate: aspulvinone dimethylallyltransferase from Aspergillus terreus”. // Biochemistry. –1978. –V.17. № 13. –P. 2696–2702.
6. Catherine Tomaro-Duchesneau, Shyamali S., Meenakshi M., Coussa-Charley M., Imen K., Mitchell L.J., Alain L., Satya P. “Probiotic Ferulic Acid Esterase Active Lactobacillus fermentum NCIMB 5221 APA Microcapsules for Oral Delivery: Preparation and in Vitro Characterization”. // Pharmaceuticals. –2012. –V.5. № 2. –P. 236–248. 7. Turzynski A., Mentlein R. “Prolyl aminopeptidase from rat brain and kidney. Action on peptides and identification as leucyl aminopeptidase”. // European Journal of Biochemistry. –1990. –V.190. № 3. –P. 509-515.
8. https://www.ncbi.nlm.nih.gov/books/NBK500003. 9. Kestelman P., Trussell J. “Efficacy of the simultaneous use of condoms and spermicides”. // Family Planning Perspectives. –1991. –V.23. № 5. –P. 226-227-232. 10. Tryon W.W. Activity Measurement in Psychology and Medicine. –New York. Springer Publishing / Plenum Press. –1991. –P. 260.
Published
2025-01-30
How to Cite
Medeu ABATOV, Ibragimdjan ABDUGAFUROV, Jasurbek MAMAJONOV, & Hamza TOSHOV. (2025). THEORETICAL STUDY AND COMPARATIVE COMPARISON OF BIOLOGICAL ACTIVITIES OF 1-(4-BROMOPHENOXY)PROPYNE-2 AND ITS DIMERIZATION PRODUCT - 1,6-BIS(4-BROMOPHENOXY)HEXADIINE-2,4. News of the NUUz, 3(3.2.1), 306-308. https://doi.org/10.69617/nuuz.v3i3.2.1.5737
Section
Articles
Copyright (c) 2025 News of the NUUz

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.