THE EFFECT OF ABAMECTIN AND THIAMETHOXAM PESTICIDES ON ISOLATED RAT LIVER MITOCHONDRIA
Nowadays, pesticides are widely used chemicals in agriculture all around the world. Even though, pesticides are the pivotal target
for the pest, they also have negative impact on mammalian organism, particularly on liver mitochondria. This research article
describes the study of the the effect of pesticides: abamectin and thiamethoxam on the swelling process of rat liver mitochondria
by opening the mitochondrial permeability transition pore (mPTP) and Fe 2+ - induced lipid peroxidation (LPO) under in vitro
conditions. The obtained data indicates that damaging effect of abamectin is more active than thiamethoxam on the opening mPTP
and LPO.
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