ABAMEKTIN VA TIAMETOKSAM PESTITSIDLARINING JIGAR MITOXONDRIYASIGA TA’SIRI
##submission.downloads##
Hozirgi kunda pestitsidlar butun dunyo bo‘ylab qishloq xo‘jaligida keng qo‘llaniladi. Pestitsidlar zararkunandalar uchun asosiy
nishon bo‘lsa-da, ular sut emizuvchilarga, xususan, jigar mitoxondriyalariga salbiy ta’sir ko‘rsatadi. Ushbu maqolada abamektin
va tiametoksam pestitsidlarining mPTP (mitochondrial permeability transitional pore) ochilishi va Fe 2+ /sitrat bilan indusirlangan
lipidlarning perekisli okdlanishi (LPO) natijasida kalamush jigar mitoxondriasi bo‘kishiga ta’siri in vitro sharoitda o‘rganilgan.
Tadqiqot natijalari shuni ko‘rsatadiki, abamektin jigar mitoxondriyasi mPTP o‘tkazuvchanligiga va LPOga tiametoksamga
nisbatan faol ta’sir ko‘rsatadi.
1. Parpieva M.J., Mirkhamidova P., Pozilov M.K., Alimova R.A. Effects of sophoroflavonoside and narcissin flavonoids on the
amount of malondialdehyde, a product of lipid peroxidation, and the activity of the enzyme cytochrome c oxidase in rat liver
mitochondria poisoned with indoxacarb pesticide // Caspian Journal of Environmental Sciences – 2023 – V. 21. №4. – P.
997-1000
2. Astiz M., Alaniz Maria J.T., Marra C.A. Effect of pesticides on cell survival in liver and brain rat issues // Ecotoxicology and
Environmental Safety – 2009 – V. 72. №7. – P. 2025-2032.
3. Kowaltowski A.J., Castilho R.F., Grijalba M.T., Bechara E.JH. and Vercesi A.E. Effect of inorganic phosphate concentration
on the nature of inner mitochondrial membrane alterations mediated by Ca 2+ ions. A proposed model for phosphate-
stimulated lipid peroxidation // J. Biol. Chem. – 1996- V. 271. -P. 2929-2934.
4. Issa S.Y., Abdel Rahman S.M., Gaber Y.M. and Soliman Nada A.H. Toxicological impact of Thiamethoxam on adult male
rats: Histopathological, biochemical, and oxidative DNA damage assessment // Toxicology Reports – 2025 – V. 14. - P. 1-9.
5. Schneider W.C., Hogeboom G.H. Cytochemical studies of mammalion tissues: the isolation of cell components by
differential centrifugation // Cancer Res. – 1951 - V. 11. – P. 1-22.
6. He L., Lemasters J. Heat shock suppresses the permeability transition in rat liver mitochondria // J. Biol. Chem. – 2003.
7. Almeida A.M., Bertoncini C.R., Borecky J., Souza-Pinto N.C. Vercesi A.E. (2006) Mitochondrial DNA damage associated
with lipid peroxidation of the mitochondrial membrane induced by Fe 2+ -citrat // An. Acad. Bras. Cienc. – V. 78. №3. – P.
505-514.
Mulkiiyat (c) 2025 «O‘zMU XABARLARI»
Ushbu ish quyidagi litsenziya asosida ruxsatlangan Kreativ Commons Attribution-NonCommercial-ShareAlike 4.0 International litsenziyasi asosida bu ish ruxsatlangan..
.jpg)
.png)
