STUDY OF THE PHARMACOLOGICAL ACTIVITIES OF 4-METHOXY-N-PHENYLBENZAMIDE IN THE PASS PROGRAM
The pharmacological activities of the amide formed from p-methoxybenzoic acid and aniline were evaluated using the PASS
program. When assessing the potential antibacterial activity of 4-methoxy-N-phenylbenzamide, the highest prediction score (Pa =
0.7479) was observed against Yersinia pestis. A comprehensive prediction analysis covering more than 4,000 types of biological
activities revealed that the highest probability values were associated with membrane-related biological processes and activities
affecting redox enzyme systems. The predicted anticancer activity of the studied compound was observed in the Hs 683 cell line
(Pa = 0.499), while the predicted activity toward normal (non-cancerous) cell lines showed relatively lower values. Overall, these
results suggest that the investigated compound may exhibit selective cytotoxic effects against cancer cells, with comparatively low
toxicity toward normal cells. According to in silico predictions of organ-specific carcinogenicity in rodents, the synthesized
compound showed a potential to induce tumor development in certain organs. In particular, the urinary bladder demonstrated the
highest probability values across all models (male and female rats and mice).
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