SYNTHESIS AND STUDY OF COMPLEX COMPOUNDS OF 3-AMINO 1,2,4-TRIAZOLE WITH SALTS Of Co (II), Ni (II) AND Cu (II)
Methods for the synthesis of complex compounds of 3-amino-1,2,4-triazole with Co (II), Ni (II) and Cu (II) salts have been
developed, and the composition and structure of the synthesized complex compounds have been studied using modern
physicochemical research methods. It was established that in complex formation reactions the 3-amino-1,2,4-triazole ligand is
coordinated through the fourth nitrogen atom of the triazole ring.
1. Romain Noel, Xinyi Song, Rong Jiang, Michael J. Chalmers, Patrick R. Griffin, and Theodore M. Kamenecka. Efficient
Methodology for the Synthesis of 3-amino-1,2,4–triazoles. // J.Org.Chem. 2009,74,19,7595-7597.
2. Иванова Ю.С., Цаплин Г.В., Попков С.В. Метод получения N 1 -замещенных – 4–(1,2,4–триазол–1–илметил)–1,2,3–
триазолов и изучение их фунгицидной активности. // Успехи в химии и химической технологии. Том ХХХIV.2020.
№8.
3. Khadir A., Verreault J., Averill DA., Inhibition of antioxidants and hyperthermia enhance bleomycin – induced cytotoxicity
and lipid peroxidation in Chinese hamster ovary cells. // Arch Biochem Biophys., 1999 Oct; 370(2):163-75.
4. MacCabe AP, Miro P, Ventura L, Ramon D. Glucose uptake in germinating Aspergillus nidulans conidia: involvement of
the creA and sorA genes. // Microbiology 149:2129-2136.
5. Fauchere JL, Boutin JA. Исследования субстратной специфичности и ингибирования серотонин-N-
ацетилтрансферазы человека. // J. Biol. Chem. 2000. 275 (12): 8794–805.
6. Lowe RF, Nelson J, Dang TN, Crowe PD, Paxuja A, McCarthy JR, Grigoriadis DE, Conlon P, Saunders J, Chen C, Szabo
T, Chen TK, Bozigian. Rational design, synthesis, and structure−activity relationships of aryltriazoles as novel
corticotropin-releasing factor-1 receptor antagonists. // HJ Med. Kimyo 2005; 48: 1540–1549. [PubMed: 15743196].
7. Marino JP, Fisher PW, Hofmann GA, Kirkpatrick RB, Janson CA, Jonson RK, Ma C, Mattern M, Meek TD, Rayan MD,
Schulz C, Smit WW, Tew DG, Tomazek TA, Veber DF, Xiong WC, Yamamoto Y , Yamashita K, Yang G, Tompson SK.
Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4- triazole pharmacophore. // J. Med. Kimyo
2007;50:3777–3785. [PubMed: 17636946].
8. Васильев А. В., Гриненко Е. В., Щукин А. О., Федулина Т. Г. Инфракрасная спектроскопия органических и
природных соединений. САНКТ-ПЕТЕРБУРГ СПбГЛТА 2007. Ст-16.
9. Шаталова Т.Б., Шляхтин О.А., Веряева Е. Методы термического анализа. - Москва: 2011.
Copyright (c) 2026 «ACTA NUUz»
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
.jpg)
1.png)
