THE EFFECT OF ALKALOID SONGORINE ON MITOCHONDRIAL RESPIRATORY RATE AND OXIDATIVE PHOSPHORYLATION PROCESS UNDER NORMAL AND SHORT-TERM STRESS
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Stress conditions adversely affect normal physiological functions, resulting in cellular dysfunctions and alterations in molecular mechanisms. Mitochondria, multifunctional organelles within cells, play crucial roles across various aspects of cell physiology, beyond their role in ATP synthesis.
Among the biologically active substances, the diterpene alkaloid songorine has an activating effect on the rate of respiration and on the processes of oxidative phosphorylation of normal and stress-induced mitochondria in vitro.
Dilnoza MURATOVA, Dildor MAHMUDOVA, & Mohinur XUJAYEVA. (2024). THE EFFECT OF ALKALOID SONGORINE ON MITOCHONDRIAL RESPIRATORY RATE AND OXIDATIVE PHOSPHORYLATION PROCESS UNDER NORMAL AND SHORT-TERM STRESS. «ACTA NUUz», 3(3.1), 75–78. https://doi.org/10.69617/nuuz.v3i3.1.1716
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2. Dzhakhangirov F.N., Sultankhodzhaev M.N., Tashkhodzhaev B., Salimov B.T. Diterpenoid alkaloids as a new class of antiarrhythmic agents. Structure-activity relationship // Chem. Nat. Compd. – 1997. – 33.P.190-202.
3. Dzhakhangirov F.N., Tursunkhodzhaeva F.M., Sultankhodzhaev M.N., Salimov B.T. Spasmolytic activity of diterpenoid alkaloids and their derivatives // Chem. Nat. Comp. – 2013. – 49. P.702-706.
4. Nesterova Yu.V., Povetieva T.N., Suslov N.I., et al. Study of the antipyretic activity of aqueous-alcoholic extracts and diterpene alkaloids obtained from alkaloid-bearing plants // Questions of Biol., Med. and pharma. chemistry. – 2010. – №10. С.44-48 (in Russian language).
5. Nesterova Y.V., Povetieva T.N., Suslov N.I., Semenov A.A., Pushkarskiy S.V. Antidepressant activity of diterpene alkaloids of Aconitum baicalense Turcz // Bull. Exp. Biol. Med. – 2011. – 151. P.425-428.
6. Khan H., Nabavi S.M., Sureda A., Mehterov N., Gulei D., Beridan-Neagoe I., Taniguchi H., Atanasov A.G. Therapeutic potential of songorine, a diterpenoid alkaloid of the genus Aconitum // Eur. J. Med. Chem. – 2018. – 153. P.29-33.
7. Dyshlovoy S.A., Kudryashova E.K., Kaune M., Makarieva T.N., et al. Urupocidin C: a new marine guanidine alkaloid which selectively kills prostate cancer cells via mitochondria targeting // Scientific Reports. – 2020. –V.10, № 9764.
8. Nezhevenko V., Yunusov M.S., Yunusov S.Y. Alkaloids of aconitum monticola structure of acomonine // Chem. Nat. Comp. – 1975. – 11. P.400-404.
9. Gornall A. G., Bardiwill C. J., David M. Determination of serum proteins by means of the Biuret reaction // J. Biol/ Chem. –1949 –Vоl. 177. N 2. –P.751-766.
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