NORMAL VA QISQA MUDDATLI STRESS CHAQIRILGAN MITOXONDRIYANING NAFAS OLISH TEZLIGI VA OKSIDLANISHLI FOSFORLANISH JARAYONIGA ZONGORIN ALKALOIDINING TA’SIRI
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В связи с тем, что стрессовые состояния отрицательно влияют на нормальные физиологические функции, они вызывают клеточные дисфункции и изменения молекулярных механизмов. Митохондрии, считающиеся многофункциональными органеллами клетки, играют важную роль в различных областях физиологии клетки, помимо синтеза АТФ.
Среди биологически активных веществ дитерпеноидный алкалоид зонгорин оказывает активирующее действие на скорость дыхания и на процессы окислительного фосфорилирования нормальных и стресс-индуцированных митохондрий in vitro.
Dilnoza MURATOVA, Dildor MAHMUDOVA, & Mohinur XUJAYEVA. (2024). NORMAL VA QISQA MUDDATLI STRESS CHAQIRILGAN MITOXONDRIYANING NAFAS OLISH TEZLIGI VA OKSIDLANISHLI FOSFORLANISH JARAYONIGA ZONGORIN ALKALOIDINING TA’SIRI. «O‘zMU XABARLARI», 3(3.1), 75–78. https://doi.org/10.69617/nuuz.v3i3.1.1716
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4. Nesterova Yu.V., Povetieva T.N., Suslov N.I., et al. Study of the antipyretic activity of aqueous-alcoholic extracts and diterpene alkaloids obtained from alkaloid-bearing plants // Questions of Biol., Med. and pharma. chemistry. – 2010. – №10. С.44-48 (in Russian language).
5. Nesterova Y.V., Povetieva T.N., Suslov N.I., Semenov A.A., Pushkarskiy S.V. Antidepressant activity of diterpene alkaloids of Aconitum baicalense Turcz // Bull. Exp. Biol. Med. – 2011. – 151. P.425-428.
6. Khan H., Nabavi S.M., Sureda A., Mehterov N., Gulei D., Beridan-Neagoe I., Taniguchi H., Atanasov A.G. Therapeutic potential of songorine, a diterpenoid alkaloid of the genus Aconitum // Eur. J. Med. Chem. – 2018. – 153. P.29-33.
7. Dyshlovoy S.A., Kudryashova E.K., Kaune M., Makarieva T.N., et al. Urupocidin C: a new marine guanidine alkaloid which selectively kills prostate cancer cells via mitochondria targeting // Scientific Reports. – 2020. –V.10, № 9764.
8. Nezhevenko V., Yunusov M.S., Yunusov S.Y. Alkaloids of aconitum monticola structure of acomonine // Chem. Nat. Comp. – 1975. – 11. P.400-404.
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2. Dzhakhangirov F.N., Sultankhodzhaev M.N., Tashkhodzhaev B., Salimov B.T. Diterpenoid alkaloids as a new class of antiarrhythmic agents. Structure-activity relationship // Chem. Nat. Compd. – 1997. – 33.P.190-202.
3. Dzhakhangirov F.N., Tursunkhodzhaeva F.M., Sultankhodzhaev M.N., Salimov B.T. Spasmolytic activity of diterpenoid alkaloids and their derivatives // Chem. Nat. Comp. – 2013. – 49. P.702-706.
4. Nesterova Yu.V., Povetieva T.N., Suslov N.I., et al. Study of the antipyretic activity of aqueous-alcoholic extracts and diterpene alkaloids obtained from alkaloid-bearing plants // Questions of Biol., Med. and pharma. chemistry. – 2010. – №10. С.44-48 (in Russian language).
5. Nesterova Y.V., Povetieva T.N., Suslov N.I., Semenov A.A., Pushkarskiy S.V. Antidepressant activity of diterpene alkaloids of Aconitum baicalense Turcz // Bull. Exp. Biol. Med. – 2011. – 151. P.425-428.
6. Khan H., Nabavi S.M., Sureda A., Mehterov N., Gulei D., Beridan-Neagoe I., Taniguchi H., Atanasov A.G. Therapeutic potential of songorine, a diterpenoid alkaloid of the genus Aconitum // Eur. J. Med. Chem. – 2018. – 153. P.29-33.
7. Dyshlovoy S.A., Kudryashova E.K., Kaune M., Makarieva T.N., et al. Urupocidin C: a new marine guanidine alkaloid which selectively kills prostate cancer cells via mitochondria targeting // Scientific Reports. – 2020. –V.10, № 9764.
8. Nezhevenko V., Yunusov M.S., Yunusov S.Y. Alkaloids of aconitum monticola structure of acomonine // Chem. Nat. Comp. – 1975. – 11. P.400-404.
9. Gornall A. G., Bardiwill C. J., David M. Determination of serum proteins by means of the Biuret reaction // J. Biol/ Chem. –1949 –Vоl. 177. N 2. –P.751-766.
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