ROLE OF K -CHANNELS IN THE RELAXANT EFFECT OF THE VINCANIDINE ETHYL IODIDE INDOLE ALKALOID
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Natural indole alkaloids act as vascular agents and exhibit vasodilatory effects. In this study, the concentration-dependent relaxant effect of vincanidine ethyl iodide – an indole alkaloid - was investigated, focusing on its action through the endothelial layer and modulation of K⁺ channels. Vincanidine ethyl iodide exhibited a potent, dose - dependent relaxant effect on endothelium - intact aortic rings, and its relaxant activity remained unaffected after pre - incubation with BaCl₂ or 4 - aminopyridine (4 - AP). The relaxant effect of vincanidine ethyl iodide (12-hydroxynorfluorocurarine ethyl iodide) involves a crucial role for both Kir and KV channels, activated via the NO/sGC/cGMP/PKG signaling pathway.
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