EFFECT OF QUERTSETINE AND DIGIDROQUERTSETINE FLAVONOIDS ON THE ACTIVITY OF ANTIOXIDANT ENZYMES
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In this article, the effects of the flavonoids quercetin and dihydroquercetin on the activity of antioxidant enzymes in rat liver
mitochondria were examined in vitro experiments. Experiments 180-200 g. conducted in white male rats. The effect of
dihydroquercetin on catalase, superoxide dismutase (SOD) enzyme activity and malon aldehyde (MDA) content in rat liver
mitochondria was compared with quercetin flavonoid.
1. Королюк М.А., Иванова Л.И., Майорова И.Г., Токарев В.Е. Методы определения активности каталазы // Москва,
Медицина – 1988. – С. 16-18.
2. Матюшин Б.Н. Определение супероксиддисмутазной активности в материале пункционной биопсии печени при ее
хроническом поражении // Лаб. дело. – 1991. – №7. – С. 16-19.
3. Рaмоновa Л.A., Стaльнaя И.Д. Метод определения гидроперекмсей липидов с помощью тиоциaнaтa aммония. В кн.
«Современные методы в биохимии». – Москвa, 1977. – С. 64-66.
4. Sofna D.S., Artanti N. Antioxidant properties of flavonoids // Med J Indones – 2014 – V.23 (№4) – P. 239-244.
5. Costa L.G., Garrick J.M., Roquè P.J., Pellacani C. Mechanisms of neuroprotection by quercetin: counteracting oxidative
stress and more // Oxid Med Cell Longev. – 2016 – V13(8) – P. 11738-11751.
6. Mukai R., Kawabata K., Otsuka S., Ishisaka A., Kawai Y., Ji Z.S., Tsuboi H., Terao J. Effect of quercetin and its
glucuronide metabolite upon 6-hydroxydopamineinduced oxidative damage in Neuro-2a cells // Free Radic Res – 2012 –
V.46: – P. 1019–1028.
7. Guven C., Sevgiler Y., Taskin E. Pyrethroid insecticides as the mitochondrial dysfunction inducers // Mitochondrial
Diseases – 2018. – P. 293-322.
8. Migliaccio V., Scudiero R., Sica R., Lionetti L., Putti R. Oxidative stress and mitochondrial uncoupling protein 2
expression in hepatic steatosis induced by exposure to xenobiotic DDE and high fat diet in male Wistar rats // Plos One –
2019. – V.25. – P. 1-24.
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