APIS MELLIFERA ASALARI XITOZANINI MIKROTO‘LQIN YORDAMIDA SINTEZ QILISH VA REOLOGIK XOSSALARINI O‘RGANISH
В данной работе изучен процесс синтеза хитозана из мёртвых пчёл Apis Mellifera с применением метода деацетилирования под действием микроволн. По сравнению с традиционной термической обработкой, данный подход значительно сокращает время реакции и снижает энергозатраты. Полученный хитозан был исследован на предмет физико-химических свойств, реологических характеристик, молекулярной массы и степени деацетилирования (DDA). Результаты показывают, что хитозан, полученный из Apis Mellifera, отличается высоким качеством и обладает перспективным потенциалом применения в биотехнологии, медицине и фармацевтике.
1. Khattak, S., Wahid, F., Liu, L. P., Jia, S. R., Chu, L. Q., Xie, Y. Y., Li, Z. X., & Zhong, C. (2019). Applications of cellulose and chitin/chitosan derivatives and composites as antibacterial materials: Current state and perspectives. Applied Microbiology and Biotechnology, 103, 1989–2006. https://doi.org/10.1007/s00253-018-9586-4
2. Marzieh, M. N., Zahra, F., Tahereh, E., & Sara, K. N. (2019). Comparison of the physicochemical and structural characteristics of enzymatic produced chitin and commercial chitin. International Journal of Biological Macromolecules,139, 270–276. https://doi.org/10.1016/j.ijbiomac.2019.07.118
3. Ixtiyarova, G. A., & Mamatova, Sh. B. (2018). Poluchenie xitina i xitozana iz medonosnogo pchelinogo podmora Apis Mellifera. Universum: Texnicheskie nauki, 5(50). http://7universum.com/ru/tech/archive/item/5931
4. Nemcev, S. V., et al. (2004). Poluchenie xitina i xitozana iz medonosnykh pchel. Prikladnaya Biokhimiya i Mikrobiologiya, (1), 46–50.
5. Swierczewska, M., Han, H. S., Kim, K., Park, J. H., & Lee, S. (2016). Polysaccharide-based nanoparticles for theranostic nanomedicine. Advanced Drug Delivery Reviews, 99, 70–84. https://doi.org/10.1016/j.addr.2015.11.015
6. Elgadir, M. A., Uddin, S., Ferdosh, S., Adam, A., Jalal, A., Chowdhury, K., & Islam, Z. (2014). Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: A review. Journal of Food and Drug Analysis, 3, 233–246. https://doi.org/10.1016/j.jfda.2014.10.008
7. Mohammed, M. A., Syeda, J. T. M., Wasan, K. M., & Wasan, E. K. (2017). An overview of chitosan nanoparticles and its application in non-parenteral drug delivery. Pharmaceutics, 9(4), 53–66. https://doi.org/10.3390/pharmaceutics9040053
8. Rehman, K. U., Hollah, C., Wiesotzki, K., Heinz, V., Aganovic, K., Rehman, R. U., … & Zhang, J. (2023). Insect-derived chitin and chitosan: A still unexploited resource for the edible insect sector. Sustainability, 15, 4864. https://doi.org/10.3390/su15064864
9. Zhao, X., Zhang, J., & Zhu, K. Y. (2019). Chito-protein matrices in arthropod exoskeletons and peritrophic matrices. In E. Cohen & H. Merzendorfer (Eds.), Extracellular Sugar-Based Biopolymers Matrices (pp. 3–56). Springer. https://doi.org/10.1007/978-3-030-12918-7_1
10. Muthukrishnan, S., Merzendorfer, H., Arakane, Y., & Kramer, K. J. (2012). Chitin metabolism in insects. In Insect Molecular Biology and Biochemistry (pp. 193–235). Elsevier. https://doi.org/10.1016/B978-0-12-384747-8.00007-7
11. Milusheva, R., & Rashidova, S. Sh. (2020). Bombyx Mori chitosan nanoparticles: Synthesis and properties. Journal of Organic Polymer Materials, 9(4), 63–73.
12. Ixtiyarova, G. A., Hazratova, D. A., & Seytnazarova, O. M. (2020). Extraction of chitosan from died honey bee Apis Mellifera. Chemical Technology, Control and Management, 2, 15–20.
13. Akmalovna, I. G., Nosirovich, U. B., Maxamatdinovich, T. S., & Safarovich, M. A. (2020). Physicochemical properties of chitin and chitosan from died honey bees Apis Mellifera of Uzbekistan. Journal of Critical Reviews, 7(4), 120–124.
14. De Oliveira, A. M., Franco, T. T., & Oliveira Junior, E. N. D. (2014). Physicochemical characterization of thermally treated chitosans and chitosans obtained by alkaline deacetylation. International Journal of Polymer Science, 2014, 1–9. https://doi.org/10.1155/2014/480150
15. Berdikulov, B., & Ixtiyarova, G. A. (2025). Ultrasound-assisted extraction of chitosan from the exoskeletons of dead honey bees. Development of Science, 5, 118–127.
16. Leke-Aladekoba, A. A. (2018). Comparison of extraction methods and characterisation of chitin and chitosan with antimicrobial and antioxidant properties from black soldier fly (Hermetia illucens) meal. Dalhousie University, Halifax, NS, Canada.
17. Gzyra-Jagieła, K., Pęczek, B., Wiśniewska-Wrona, M., & Gutowska, N. (2019). Physicochemical properties of chitosan and its degradation products. In L. A. M. Broek & C. G. Boeriu (Eds.), Chitin and Chitosan (pp. 61–80). Wiley. https://doi.org/10.1002/9781119450436.ch4
18. Jiménez-Gómez, C. P., & Cecilia, J. A. (2020). Chitosan: A natural biopolymer with a wide and varied range of applications. Molecules, 25, 3981. https://doi.org/10.3390/molecules25173981
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