MEZENXIMAL ILDIZ HUJAYRALAR EKZOSOMALARINING BIOTEXNOLOGIYADAGI AHAMIYATI
##submission.downloads##
Mazkur maqolada mezenximal ildiz hujayralar (MSC) tomonidan ajratiladigan ekzosomalarning biotexnologiyadagi ahamiyati
yoritilgan. Ekzosomalar – hujayralararo axborot uzatishda ishtirok etuvchi nanoo‘lchamli biologik vezikulalar bo‘lib, ular oqsillar,
lipidlar va nuklein kislotalarni tashish orqali regenerativ jarayonlarni faollashtiradi. MSC ekzosomalari immunomodulyator,
yallig‘lanishga qarshi va regeneratsion xususiyatlarga ega bo‘lib, ularni tibbiyot, farmatsevtika, kosmetologiya hamda diagnostika
sohalarida qo‘llash istiqbollari katta. Maqolada MSC ekzosomalarining ishlab chiqarish bosqichlari, ularning afzalliklari, amaliy
qo‘llanilishi va biotexnologik imkoniyatlari tahlil qilingan.
1. Valadi H., Ekström K., Bossios A., et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of
genetic exchange between cells. Nat Cell Biol. 2007.
2. Théry C., Witwer K.W., et al. MISEV2018: Minimal information for studies of extracellular vesicles. J Extracell Vesicles.
2018.
3. Kordelas L., Rebmann V., Ludwig A.K., et al. MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-
host disease. Leukemia. 2014.
4. Lai R.C., Arslan F., Lee M.M., et al. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell
Res. 2010.
5. Wang X.-Y., Zhang T., Wang H.-Z. Mesenchymal stem cell-derived exosomes as drug delivery vehicles: an update. 2013.
6. Sanyal K., Banerjee A.G. Exosomes: A Brief Review of Biology and Medical Applications. 2024.
7. Roszkowski S. Therapeutic potential of MSC-derived exosomes for regenerative medicine applications. 2024.
8. Mukhitdinova M.Yo., Shakirova S.M., Yusupova U.M. Modern Molecular And Biotechnological Approaches To The
Diagnosis, Prognosis, And Treatment Of Uterine Fibroids (Literature Review). 2025.
9. Ferguson S., Lai R.C., et al. Advances and challenges in large-scale MSC-exosome production and bioengineering. Front
Pharmacol. 2025.
10. Gimona M., Brizzi M.F., et al. Extracellular vesicles in regenerative medicine: Focus on mesenchymal stem cell derived
exosomes. Transfusion and Apheresis Science. 2023.
11. Mendt M., Kamerkar S., et al. MSC-derived exosomes as a next-generation cell-free therapeutic for oncology and tissue
repair. Molecular Therapy. 2022.
12. Riazifar M., Pone E.J., Lötvall J., Zhao W. Stem cell extracellular vesicles: Extended messages of regeneration. Annual
Review of Pharmacology and Toxicology. 2017.
13. Phinney D.G., Pittenger M.F. Concise Review: MSC-derived exosomes for regenerative medicine: Mechanisms of action
and clinical applications. Stem Cells. 2017.
14. Lener T., Gimona M., et al. Applying extracellular vesicles based therapeutics in clinical trials — an ISEV position paper.
Journal of Extracellular Vesicles. 2015.
15. Li Q., Fang J., et al. Bioengineered MSC-derived exosomes for targeted drug delivery and genetic modification. Advanced
Drug Delivery Reviews. 2023.
16. Yáñez-Mó M., Siljander P.R.M., Andreu Z., et al. Biological properties of extracellular vesicles and their physiological
functions. Journal of Extracellular Vesicles. 2015.
17. Kalluri R., LeBleu V.S. The biology, function, and biomedical applications of exosomes. Science. 2020.
Mulkiiyat (c) 2025 «O‘zMU XABARLARI»
Ushbu ish quyidagi litsenziya asosida ruxsatlangan Kreativ Commons Attribution-NonCommercial-ShareAlike 4.0 International litsenziyasi asosida bu ish ruxsatlangan..
.jpg)
.png)
