SYNTHESIS, STRUCTURE, AND PROPERTIES OF ACETOACETANILIDE BENZOYLHYDRAZONE
This study investigates the synthesis, structure, and biological activity of acetoacetanilide benzoylhydrazone. The chemical
structure was confirmed by X-ray diffraction analysis, tautomeric forms were examined using quantum-chemical calculations, and
the crystal structure was analyzed through Hirshfeld surface analysis. Molecular docking results demonstrated effective binding
with the 4FDO protein, indicating that the compound is a promising biologically active agent.
1. Zhu H. et al. Synthesis, Characterization and Antibacterial Activities of Manganese (II), Nickel (II), Copper (II) and Zinc (II)
Complexes of the Hydrazone Compounds Derived from 1-Phenyl-3-methyl-4-acyl-pyrazole and Benzoyl Hydrazine //Asian
J. Chem. – 2013. – Т. 25. – С. 8444-8446.
2. Mali S. N. et al. Mini-review of the importance of hydrazides and theirderivatives - Synthesis and biological activity
//Engineering proceedings. – 2021. – Т. 11. – №. 1. – С. 21.
3. S.Z.Sattorova, E.A.Xudoyorova, S.F.Abduraxmonov, B.B.Umarov. (Z)-3-(2- enzоilgidrаziliden)-n-fenilbutаnаmid sintezi,
tuzilishi vа spektrоskоpik tаhlili // Development of science. 2025/ Volume 5.63-69 b.
4. S.Z.Sattorova, E.A.Xudoyorova, S.F.Abduraxmonov, B.B.Umarov, (E)-3-(2-benzoilgidraziliden)-N fenilbutanamidning
Hirshfeld sirt tahlili// Development of science. 2025/6, Volume 1.386-392 b.
5. Sh G. B. et al. Online molecular docking and analysis of biological activity of cyanuric acid derivatives //Universum: химия
и биология. – 2022. – №. 6-4 (96). – С. 12-16.
6. Сатторова С. З. и др. Синтез и рамановский спектр (Z)-3-(2-бензоилгидразилиден)-N-фенилбутанамида //Journal of
Advances in Engineering Technology. – 2025. – №. 3. – С. 30-33.
7. Сатторова С. З. К. и др. Термический анализ ацетоацетанилидных ароилгидразонов //Universum: химия и биология.
– 2025. – Т. 3. – №. 11 (137). – С. 21-25.
8. Martins M. B., Carvalho I. Diketopiperazines: biological activity and synthesis //Tetrahedron. – 2007. – Т. 63. – №. 40. – С.
9923-9932.
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