C-4 KOMPOZITSIYASINING MARKAZIY VA PERIFERIK NERV TIZIMINING FUNKSIONAL HOLATIGA TA’SIRINI IN VIVO SHAROITIDA O‘RGANISH
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Mazkur maqolada dori vositasini yaratish jarayonida xavfsizlikni o‘rganish bo‘yicha tadbirlar majmuasiga asab tizimiga
farmakologik vositalarni yaratish va amaliy tibbiyotga tatbiq etishda ularning nafaqat asosiy terapevtik faolligini, balki
organizmning hayotiy muhim tizimlariga ko‘rsatadigan ta’sirini ham har tomonlama baholash muhim ahamiyatga ega. C-4
kompozisiyasi terapevtik 10 mg/kg doza hamda undan ikki baravar yuqori - 20 mg/kg dozada tinchlantiruvchi vositalar bilan
birgalikda qo‘llash uchun maqbul hisoblanadi. Ayrim uyqu chaqiruvchi vositalarga (xloralgidrat) nisbatan esa antagonist ta’sir
namoyon qiladi.
1. European Directive 2010/63/EU on the protection of animals used for scientific purposes. September 22, 2010. Official
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Миронова. М.: Гриф и К, 2012. - 944 с.
3. OECD (2001) Guideline for testing of chemicals. Acute Oral Toxicity – Fixed Dose Procedure No 420.
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human use. International conference on harmonisation of technical requirements for registration of pharmaceuticals for
human use. S2(r1). Current Step 4 version dated 9 November 2011.
5. ГОСТ Р 57146-2016 Лекарственные средства. для медицинского применения. Изучение канцерогенности
лекарственных средств и вспомогательных веществ (ЮН S1А:1995, Guideline on need for carcinogenicity of
pharmaceuticals, MOD) (S1B:1997, Testing for carcinogenicity of pharmaceuticals, MOD) (S1C(R2):2008, Dose selection
for carcinogenicity studies of pharmaceuticals, MOD.
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