QURUQ INKUBATORDA YETISHTIRILGAN EUPLOID EMBRIONLARNI KO‘CHIRISHDA GIALURON KISLOTASI BO‘LGAN MUHITNING HOMILADORLIK VA TIRIK TUG‘ILISH HOLATLARIGA TA’SIRI
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YRTning muvaffaqiyati to‘g‘ridan-to‘g‘ri ko‘plab omillarga, shu jumladan embrionlarning sifatiga, stimulyatsiya protokoliga va ishlatiladigan muhitga bog‘liq. Gialuron kislotasi (GK) embrionning endometriyga yopishishini yaxshilaydigan komponent sifatida e’tiborni tortdi, bu esa o‘z navbatida homiladorlik va tirik tug‘ilish darajasini oshirishi mumkin. Tadqiqotning maqsadi quruq inkubator sharoitida o‘stirilgan euploid embrionlarni o‘tkazishda gialuron kislotasi bo‘lgan muhitning homiladorlik va tirik tug‘ilish darajasiga ta’sirini baholash edi. Tadqiqot 19-44 yoshdagi 255 bemorlarda o‘tkazildi, ularga bitta euploid embrion ko‘chirildi. O‘tkazishdan oldin blastotsistlar ikkita muhitdan birida 3 soat davomida inkubatsiya qilingan. Asosiy guruh GK tarkibiga ega bo‘lgan muhit va GK bo‘lmagan muhit nazorat guruhini tashkil etdi. Natijalar shuni ko‘rsatdiki, quruq inkubator sharoitida gialuron kislotasi muhitidan foydalanish - bitta euploid blastotsist o‘tkazilganda homiladorlik darajasini oshirishi mumkin.
Urman et al. (2008) Effect of hyaluronan-enriched transfer medium on implantation and pregnancy rates after day 3 and day 5 embryo transfer: a prospective randomized study. Fert Steril 90(3):604-12.
2. Bontekoe S et al. (2010) Cochrane Database Syst Rev. Jul 7;(7):CD007421.
3. Bontekoe S et al., (2014) Cochrane Database Syst Rev. Feb 25;2:CD007421.
4. Balaban B et al. (2011) Effect of hyaluronan-enriched transfer medium on take home baby rate after day 3 and day 5 embryo transfers: a prospective randomized study. Hum Reprod. July 15(15):i24.
5. Hashimoto S et al. (2014) EmbryoGlue improvespregnancy and implantation rates: Results from a Metaanalysis on almost 10,000 embryo transfers. Reprod BioMed Online. 28(Suppl 1):S7-S8.
6. Meintjes M (2012) Media composition; macromolecules and embryo growth. Methods Mol Biol. 912:107-27.
7. Morbeck et al. (2014) Composition of protein supplements used for human embryo culture. J Assist Reprod Genet. 12:1703-11.
8. Blake et al. (2002) Protein Supplementation of human IVF culture media. J Assist Reprod Genet. 19:137-43.
9. Leonard et al. (2013) Variability in protein quality used for embryo culture: embryotoxicity of the stabilizer octanoic acid. Fertil Steril. 100:544- 549.
10. Lane et al. (2003) Cryo-survival and development of bovine blastocysts are enhanced by culture with recombinant albumin and hyaluronan. Mol Reprod Dev 64:70-78.
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