HISTOLOGICAL CHARACTERISTICS OF EXPERIMENTAL CROHN’S DISEASE IN RATS

  • Bakridin ZARIPOV O‘zbekiston Milliy universiteti professori, akademik, b.f.d
  • Shahodat UMMATQULOVA O‘zbekiston Milliy universiteti mustaqil izlanuvchisi
  • Gulsara AXMEDOVA O‘zbekiston Milliy universiteti katta o‘qituvchisi, PhD
  • Sardor ZUBTIYEV Toshkent tibbiyot akademiyasi assistenti
Keywords: experimental modeling, inflammatory bowel diseases, Crohn’s disease, ulcerative colitis, histology

Abstract

The article presents the results of histological studies of internal organs (liver, lungs, brain and intestine) in rats with chronic experimental Crohn’s disease in laboratory conditions. It was found that during Crohn’s disease, microstructural changes in the parenchyma of internal organs (liver, lungs, brain and intestine) are accompanied by the development of dystrophic and necrobiotic processes in cells.

References

Belluzzi A. et al. Polyunsaturated fatty acids and inflammatory bowel disease //The American journal of clinical nutrition. – 2000. – Т. 71. – №. 1. – С. 339S-342S.

Ng S. C. et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies //The Lancet. – 2017. – Т. 390. – №. 10114. – С. 2769-2778.

Khalili H. et al. Adherence to a Mediterranean diet is associated with a lower risk of later-onset Crohn’s disease: results from two large prospective cohort studies //Gut. – 2020. – Т. 69. – №. 9. – С. 1637-1644.

Fiorino G. et al. Preventing collateral damage in Crohn’s disease: the Lémann index //Journal of Crohn’s and Colitis. – 2016. – Т. 10. – №. 4. – С. 495-500.

Green N. et al. A review of dietary therapy for IBD and a vision for the future //Nutrients. – 2019. – Т. 11. – №. 5. – С. 947.

Yilmaz B. et al. Microbial network disturbances in relapsing refractory Crohn’s disease //Nature medicine. – 2019. – Т. 25. – №. 2. – С. 323-336.

Feuerstein J. D., Cheifetz A. S. Crohn disease: epidemiology, diagnosis, and management //Mayo Clinic Proceedings. – Elsevier, 2017. – Т. 92. – №. 7. – С. 1088-1103.

Gomollón F. et al. 3rd European evidence-based consensus on the diagnosis and management of Crohn’s disease 2016: part 1: diagnosis and medical management //Journal of Crohn’s and Colitis. – 2017. – Т. 11. – №. 1. – С. 3-25.

Pochard C. et al. The multiple faces of inflammatory enteric glial cells: is Crohn’s disease a gliopathy? //American Journal of Physiology-Gastrointestinal and Liver Physiology. – 2018. – Т. 315. – №. 1. – С. G1-G11.

Zaripov B.,Adamchuk D.K., Gurman E., Akhmedova G., Niyazmetov B., Ummatqulova Sh. Influence of papaverine and commercial dietary supplements on blood glucose and body weight in obese animals // Инфекция, иммунитет ва фармакология – Тошкент, 2023. – № 2. – Б. 20-29.

Zaripov B.,Ummatqulova Sh.U., Mamatova M., Xudoyorov Yu., Quvatova N., Axmedova G.B. Kron kasalligida hazm tizimining morfofiziologiyasi // Инфекция, иммунитет ва фармакология – Тошкент, 2023. – № 2. – Б. 82-90.

Published
2024-11-26
How to Cite
Bakridin ZARIPOV, Shahodat UMMATQULOVA, Gulsara AXMEDOVA, & Sardor ZUBTIYEV. (2024). HISTOLOGICAL CHARACTERISTICS OF EXPERIMENTAL CROHN’S DISEASE IN RATS. News of the NUUz, 3(1.1), 69-72. https://doi.org/10.69617/nuuz.v3i1.1.5380