YANGI 1,2,4-TRIAZOL VA 1,2,4-TRIAZOL–TIAZIDIN HOSILALARINING SINTEZI VA REAKSION QOBILIYATI
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In this study, the synthesis, reactivity, and structural features of 1,2,4-triazole and 1,2,4-triazole–thiazidine derivatives were investigated. The research demonstrated that N-acyl-1,3,4-oxadiazole derivatives are efficiently converted into 1,2,4-triazole compounds in the presence of hydrazine hydrate, yielding the products in high amounts. In addition, various N-acyl derivatives were synthesized based on the molecule 4-(6-phenyl-7H-[1,2,4]-triazolo[3,4-b][1,3,4]thiazin-3-yl)aniline, which exhibits antiepileptic activity. The structures of the synthesized compounds were confirmed using ^1H NMR and IR spectroscopic techniques. These newly obtained compounds show high bioactivity and significant pharmacological potential, and are considered promising candidates for further investigation of antibacterial, antifungal, and other biological activities. The results contribute to the development of new directions in pharmaceutical chemistry and biochemical research.
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