EMBRION RIVOJLANISHI: GURUHLI KULTIVATSIYANING INDIVIDUAL TIME-LAPSE TIZIMIGA NISBATAN USTUNLIGI
The efficiency of embryo development in vitro is strongly influenced by the characteristics of the culture microenvironment, particularly medium volume, metabolic stability, and the presence of paracrine signaling between embryos. Group embryo culture provides a more physiologically supportive environment by preserving inter-embryonic communication and reducing metabolic stress, thereby enhancing developmental competence. In contrast, individual culture within time-lapse systems, despite offering continuous morphokinetic monitoring, is limited by small medium volume and the absence of paracrine interaction, which may restrict developmental potential. Analysis of 436 IVF cycles demonstrated that the proportion of good-quality Day-5 blastocysts was higher in group culture (40.8%) compared with individual time-lapse culture (35.4%), while fertilization rates and late
Natural sciencesblastocyst formation on Days 6–7 were comparable. These findings indicate that embryo development is determined primarily by the biological and metabolic properties of the microenvironment rather than imaging technology alone, positioning group culture as a more biologically advantageous approach in many laboratory settings.
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