GLYCYRRHIZIN IS A SUBSTANCE THAT REPRESENTS THE VALUE OF THE LICORICE PLANT
It is known that today it is extracted from plants naturally the demand for compounds is increasing. The reason is that the drug is
mainly made of natural compounds used as a tool. From substances extracted from natural compounds low toxicity of the
prepared medicines, compatibility with the living organism and with its specific activity, it differs from synthetic drugs. One such
plant belonging to the Leguminosae family is licorice, the scientific name of which is Glycyriza glabra Linn. This plant has high
medicinal properties, several compounds such as glycyrrhizin, glycyrrhizic acid, isoliquiritin have been found, and anti-cancer,
anti-diabetic, anti-asthmatic, anti-inflammatory, anti-microbial and antispasmodic activities of these substances have been
determined. In addition, these products play a major role in hepatoprotective, immunological, and memory-enhancing activities.
1. O‘zbekiston Respublikasi Vazirlar Mahkamasining 2018-yil 27-yanvardagi «O‘zbekiston Respublikasida qizilmiya va
boshqa dorivor o‘simliklarni yetishtirish hamda sanoat usulida qayta ishlashni yanada rivojlantirish chora-tadbirlari
to‘g‘risida»gi 63-sonli Qarori.
2. Acharaya S.K, Dasarathy S, Tandon A, Joshi Y.K, Tandon B.N. Preliminary open trial oninterferon stimulator (SNMC)
derived from Glycyrrhiza glabra in the treatment of subacute hepatic failure. Indian J Med Res 1993.p.69–74.
3. Arora R, Chawla R, Marwah R, Arora P, Sharma RK, Kaushik V, Goel R, Kaur A, Silambarasan M, Tripathi RP, Bhardwaj
JR Potential of complementary and alternative medicine in preventive management of novel H1N1 Flu (Swine Flu)
pandemic: thwarting potential disasters in the Bud.2011.p.1-16.
4. Badam, L. Ammonium Salt of Glycyrrhizic Acid as an Antiviral. Natl. Med. J. India 1997, 10, 98.
5. Bradley PR (ed) British herbal compendium, vol 1. BHMA, Bournemouth 1996. p. 239.
6. Chen, F.; Chan, K.H.; Jiang, Y.; Kao, R.Y.T.; Lu, H.T.; Fan, K.W.; Cheng, V.C.C.; Tsui,W.H.W.; Hung, I.F.N.; Lee,
T.S.W.; et al. In Vitro Susceptibility of 10 Clinical Isolates of SARS Coronavirus to Selected Antiviral Compounds. J. Clin.
Virol. 2004, 31, 69–75.
7. Crance, J.M.; Biziagos, E.; Passagot, J.; van Cuyck-Gandré, H.; Deloince, R. Inhibition of Hepatitis A Virus Replication In
Vitro by Antiviral Compounds. J. Med. Virol. 1990, 31, 155–160. [CrossRef]
8. Crance, J.M.; Lévêque, F.; Biziagos, E.; van Cuyck-Gandré, H.; Jouan, A.; Deloince, R. Studies on Mechanism of Action
of Glycyrrhizin against Hepatitis A Virus Replication in Vitro. Antiviral Res. 1994, 23, 63–76.
9. Crance, J.M.; Scaramozzino, N.; Jouan, A.; Garin, D. Interferon, Ribavirin, 6-Azauridine and Glycyrrhizin: Antiviral
Compounds Active against Pathogenic Flaviviruses. Antivir. Res. 2003, 58, 73–79. [CrossRef].
10. Dagar J.C. et al. Liquorice (Glycyrrhiza glabra): a potential salt-tolerant, highly remunerative medicinal crop for
remediation of alkali soils //Current Science. 2015. p. 1683-1688.
11. De Clercq E Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection. Med
Res Rev 1994.p.323–349.
12. Diomede L. et al. Can antiviral activity of licorice help fight COVID-19 infection? //Biomolecules. – 2021. – Т. 11. – №. 6.
– С. 855.
13. DjegrassiC., OsieckiJ., ClossonW. Constitution of the ester obtained by oxidation of methylglycyrrhetate acetate // J. Am.
Chem. Soc. - New York, 1959. - V. 81. - P. 458- 460.
14. Haraguchi H, Tanimato K, Tamura Y, Kinoshita T Antioxidative and Superoxide scavenging activities of retrochalcones in
Glycyrrhiza inflate. Phytochemistry 1998 p.125–129.
15. Hikino H, Wagner H, Farnsworth N.R (eds) Recent research on oriental medicinal plants. Economic and medicinal plant
research, vol 1. Academic, London, 1985. p 53–85.
16. İsaev Y.T. Glitsirrizin kislotasi hosilalari va ularning biologik faolligi. Kimyo fan. nom. … dis. - Toshkent. 2000. - 56-57
b.
17. Jeong HG, You HJ, Park SJ, Moon AR, Chung YC, Kang SK, Chun HK Hepatoprotective effects of 18β-glycyrrhetinic
acids on carbon tetrachloride-induced liver injury, inhibition of cytochrome P450 2E1 expression. Pharmacol
Res.2002.p.:221–227.
18. Lin C.-C.; Wang P.-H. Intravenous Glycyrrhizin Improved Serum Transaminases Rapidly in a Chronic Hepatitis B Patient
with Acute Exacerbation. J. Formos. Med. Assoc. Taiwan Yi Zhi 2015, 114, 188–189. [CrossRef].
19. Saeedi M, Morteza-Semnani K, Ghoreishi MR The treatment of atopic dermatitis withlicorice gel. J Dermatol Treat 2003 p.
153–157.
20. Sato H, Goto W, Yamamura J, Kurokawa M, Kageyama S, Takahara T, Watanabe A, Shiraki K Therapeutic basis of
glycyrrhizin on chronic hepatitis B. Antivir Res 1996.p.171–177.
21. Wildhirt E. Experience in Germany with Glycyrrhizinic Acid for the Treatment of Chronic Viral Hepatitis. In Viral
Hepatitis and Liver Disease; Nishioka K., Suzuki H., Mishiro S., Oda T., Eds.; Springer: Tokyo, Japan, 1994; pp. 658–661.
22. Yamamura Y, Kawakami J, Santa T, Kotaki H, Uchino K, Sawada Y, Tanaka N, Iga T Pharmacokinetic profile of
glycerrhizin in healthy volunteers by a new high-performance liquid chromatographic method. J Pharm Sci 1992 p.1042–
1046.
23. Балтина Л.А., Рыжова С.А., Васильева Е.В., Толстиков Г.А.Синтезтритерпеновыхгликопептидов, содержащих
алкиловые эфиры L-аминокислот // Хим. природ.соедин. - Ташкент. 1994. - №2. С. 261-268. 298.
24. Лерман Ф.С. О содержании глицирризиновой кислоты в корнях солодок, выращенных в различных условиях. в кн:
Материалы по био-логии видов рода Glycyrrhiza L. Ташкент, ФАН, 1970, с.188-194.
25. Саидов Д.К., Шамсувалиева Л.А. Особенности корневой системы Glycyrrhiza glabra L. в условиях
разнокачественного засоления почв. вкн: Биологические и структурные особенности полезных растений
Узбекистана. Ташкент, ФАН,1979, с. 75-78.
Copyright (c) 2026 «ACTA NUUz»
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
.jpg)
1.png)
