KABACHNIK-FIELDS REACTIONS WITH 2,3-TRIMETHYLENE-1,2,3,4- TETRAHYDROHINAZOLON-4
In the article synthesized 2,3-trimethylene-3,4-dihydrohinazolon from anthranilic acid and pyrrolidone-2 in the presence different
agents, such as PCl 5 , POCl 3 . Its reduction reaction with NaBH 4 carrying out. Obtained 2,3-trimethylene-1,2,3,4-
tetrahydrohinazolon this three-component coupling of a carbonyl, an amine and a hydrophosphoryl compoud leads to α-
aminophosphonates, phosphorous acid-formaldehyde; aldehydes in three component system; aminomethylphosphonic acid
synthesis based on kabachnik-filds reaction. 2,3- trimethylene-3,4-dihydrohinazalon 55% da product obtained. The reason of low
reaction yield was studied. Structures were confirmed using IR and 1 H NMR spectroscopies. Obtained product reduced using
NaBH 4 and 2,3-trimethylene-1,2,3,4-tetrahydrohinazolon synthesis was carried out with high yield. 2,3- trimethylene-1,2,3,4-
tetrahydrohinazolon and respective aminophosphonic acids were synthesized in three component system with high yield.
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