РЕАКЦИИ КАБАЧНИК-ПОЛЕЙ С 2,3-ТРИМЕТИЛЕН-1,2,3,4-ТЕТРАГИДРОХИНАЗОЛОН-4
В статье синтезирован 2,3-триметилен-3,4-дигидрохиназолон из антраниловой кислоты и пирролидона-2 в присутствии
различных агентов, таких как PCl5, POCl3. Проведение реакции его восстановления с использованием NaBH 4 . Получен
2,3-триметилен-1,2,3,4-тетрагидрохиназолон. Трехкомпонентное соединение карбонила, амина и гидрофосфорильного
соединения приводит к α-аминофосфонатам фосфористой кислоты-формальдегида; альдегиды в трехкомпонентной
системе; Синтез аминометилфосфоновой кислоты на основе реакции Кабачника-Филдса. Получен 2,3-триметилен-3,4-
дигидрохиназалон 55% да продукта. Изучена причина низкого выхода реакции. Структуры подтверждены методами ИК-
и ЯМР 1Н-спектроскопии. Полученный продукт восстановлен с помощью NaBH4 и синтез 2,3-триметилен-1,2,3,4-
тетрагидрохиназолона проведен с высоким выходом. 2,3-триметилен-1,2,3,4-тетрагидрохиназолон и соответствующие
аминофосфоновые кислоты синтезированы в трехкомпонентной системе с высоким выходом.
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