REACTIONS OF AMIDES OF 4-CARBOXYPYRIDINE WITH p-ANIZIDINE, p-BROMANILINE, 2,6-XYLIDINE, 2,4-DICHLORANILINES
Corresponding amides were synthesized from reactions of 4-carboxypyridic acid with p-anisidine, p-bromaniline, 2,6-xylidine, 2,4-dichloroanilines. The influence of the nature of the solvent on the course of the reactions was studied, and the results obtained from the reactions carried out in different solvents were compared. It was found that 4-carboxypyridine acid reacts with some aromatic amines to form amides when heated in non-polar solvents. The physical constants of the synthesized amides were determined. The structure of the reaction products was analyzed using IR- and 1N and 13S NMR spectroscopy methods.
Aghayan M.M., Tavana M.M., Boukherroub R. Sulfonated reduced graphene oxide as a highly efficient catalyst for direct amidation of carboxylic acids with amines using ultrasonic irradiation // UltrasonicsSonochemistry. 29, 2016. -P. 371-379.
Tamaddon F., Aboee F., Nasiri A. ZnOnanofluid as a structure base catalyst for chemoselectiveamidation of aliphatic carboxylic acids // Catalysis Communications 16, 2011. -P. 194-197. 3. Morrison R., Boyd R. Organicheskaya ximiya. Per. s angl. Demyanovich V.M., Smita V.A. M.: Mir, 1974.
Zhang Q, Chen C. Direct acylation of aryl amines usingdimethylformamide and dimethylacetamideas the acyl resources //Journal of Saudi Chemical Society. 2016, 20. -P. 114-119.
Sonawane R.B., Rasal N.K., Jagtap S.V. Nickel-(II)-Catalyzed N‑Formylation and N‑Acylation of Amines //American Chemical Society, Organic Letters. 2017, 19, -P. 2078-2081.
Grimmel H.W.,Guenther A.,Morgan J.F. Phosphazo compounds and their use in preparing amides // Journal of The American Chemical Society.Washington, 1946. Vol. 68,№4.-P. 539-541.
Kawagoe Y., Moriyama K., Togo H. Facile preparation of amides from carboxylic acids and amines withion-supported Ph3P//Tetrahedron. 69, 2013. -P. 3971-3977.
Menezes F.G., Kolling R., Bortoluzzi A.J., Gallardo H., Zucco C. Hexabromoacetone as tribromoacetylating agent of alcohols and amines and as mediator in the conversion of carboxylic acids into amides in the presence of triphenylphosphine // Tetrahedron Letters. 50, 2009. -P. 2559-2561.
.jpg)
1.png)
