SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2,2'-(5-FLUORO-2,4-DIOXOPYRIMIDINE-1,3(2H,4H)DIYL)BIS(N-(3-(TRIFLUOROMETHYL)PHENYL)ACETAMIDE
In this study, a new compound was synthesized by the reaction of the chloroacetylation product of 3-trifluoromethyl aniline with 5-fluorouracil (5-Fu). The process was carried out in 2 stages, firstly, the chloroacetylation reaction of 3-trifluoromethyl aniline was carried out, and in the second stage, the new product 2,2'-(5-fluoro-2,4-dioxopyrimidine-1,3(2H,4H)-diyl)bis(N-(3-(trifluoromethyl)phenyl) acetamide was synthesized based on the reaction of the obtained compound with 5-Fu. The structure of the product was confirmed using 1H, 13C NMR, IR and Mass spectrometry methods. The liquefaction temperature, reaction yield, solubility of the obtained product were determined, and 3 cancer cells were selected to test the biological activity: Hela (cervical cancer), HT-29 (colon cancer cell) and MCF-7 (breast cancer cell).
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