SYNTHESIS AND STUDY OF THE BIOLOGICAL ACTIVITY OF A NEW DERIVATIVE OF 5-FLUOROURACIL BASED ON 3-FLUORO 4-NITRO N-CHLOROACETYL ANILINE
In this work, a novel product was synthesized by the reaction of the chloroacetylation product of 3-fluoro 4-nitro aniline with 5fluorouracil. The process was carried out in 2 steps, firstly, the chloroacetylation reaction of 3-fluoro 4-nitro aniline and in the second step, the synthesis of a new product with 5-fluorouracil from the intermediate compound. The structure of the product was confirmed using 1H, 13C NMR, IR and Mass spectrometry methods. The liquefaction temperature, reaction yield, solubility of the obtained product were determined and the biological activity was tested in 2 cancer cells: HT-29 (colon cancer cell) and MCF-7 (breast cancer cell).
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