5-FTORURATSILNING 3-FTOR 4-NITRO N-XLORATSETIL ANILIN ASOSIDAGI YANGI HOSILASINI SINTEZ QILISH VA BIOLOGIK FAOLLIGINI O’RGANISH
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Ushbu maqolada 3-ftor 4-nitro anilinning xloratsetillash mahsulotining 5-ftoruratsil bilan reaksiyasi yordamida yangi birikma sintez qilindi. Jarayon 2-bosqichda amalga oshirilgan bo‘lib, dastlab 3-ftor 4-nitro anilinning xloratsetillash reaksiyasi o‘tkaziladi va ikkinchi bosqichda olingan birikmaning 5-ftoruratsil bilan reaksiyasi asosida yangi mahsulot sintez qilindi. Mahsulotning tuzilishi 1H, 13C YaMR, IQ va Mass spektrometriya usullari yordamida tasdiqlandi. Olingan mahsulotning suyuqlanish harorati, reaksiya unumi, eruvchanligi aniqlandi va biologik faolligini tekshirish uchun 2 ta saraton hujayrasi: HT-29 (yo‘g‘on ichak saraton hujayrasi) va MCF-7 (ko‘krak saratoni hujayrasi)larda o‘rganildi.
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