FLAVONOID COMPOSITION OF PYRUS PYRASTER FROM THE SOUTH-EASTERN PART OF BAKHMAL DISTRICT, JIZZAKH REGION, REPUBLIC OF UZBEKISTAN
This article presents the results of a comprehensive study on the flavonoid composition of wild pear (Pyrus pyraster) fruits growing in the southeastern part of the Bakhmal district in the Jizzakh region of Uzbekistan. Using high-performance liquid chromatography (HPLC) with diode array detection, the main flavonoid compounds were identified and quantified: gallic acid, rutin, isoquercetin, and hyperoside. It was established that the highest content of flavonoids is observed in aqueous extracts, with rutin being the dominant compound (39.06 ± 0.04 mg/100 g of dry matter). A comparison of extraction efficiency using various solvents (water, 40% and 70% ethanol) was conducted, which enabled the determination of optimal conditions for isolating biologically active substances. The research results demonstrate the high potential of Pyrus pyraster as a source of natural antioxidants for applications in pharmaceutical, food, and cosmetic industries. Particular attention was given to the prospects of using these extracts in functional foods and nutraceuticals.
1. Kumar, S., & Pandey, A. K. (2013). Chemistry and biological activities of flavonoids. Scientific World Journal, 2013, 162750.
2. Li, X., et al. Bioactive compounds in pear cultivars. Journal of Agricultural and Food Chemistry, 2014, Vol. 62(3), pp. 658– 668.
3. Ganeshpurkar, A. Rutin: A therapeutic potential. Chemico-Biological Interactions, 2017, Vol. 273, pp. 154–159.
4. Kolniak-Ostek, J.; Kłopotowska, D.; Rutkowski, K. P. Comparative study of phenolic compounds in wild and cultivated pears. Food Chem. 2020, Vol. 321, 126706.
5. M. Brahem, R. Ouni. IRESA, Университет Суса Франция; INRA, университет Авиньона и Пэ-Дю-Воклюз, Тунис, 2017.
6. J. Kolniak-Ostek, D. Kłopotowska, K.P. Rutkowski. Вроцлавский университет окружающей среды и наук о жизни, Вроцлав, Польша; Научно-исследовательский институт садоводства, Польша, 2020.
7. X. Li, T. Wang, B. Zhou, W. Gao, J. Cao, L. Huang. Тяньцзиньский университет, Тяньцзинь, Китай, 2014. 8. Izabela Rychlińska, Jan Gudej. Qualitative and quantitative chromatographic investigation of flavonoids in Pyrus communis L. flowers. Acta Poloniae Pharmaceutica - Drug Research. 2003 January, Vol. 60(1), pp. 81-5. 9. Yu Geon Lee, Wol Kim, Jeong-Yong Cho, Tae-Il Jeon. Coumaroyl quinic acid derivatives and flavonoids from immature pear (Pyrus pyrifolia nakai) fruit. Food Sci. Biotechnol. 2013, Vol. 22(3), pp. 803-810. 10. Chand, P.; Kumar, H.; Jain, R.; Jain, A.; Jain, V. Flavonoids as omnipotent candidates for cancer management. S. Afr. J. Bot. 2023, Vol. 158, pp. 334–346. 11. Ganeshpurkar, A.; Saluja, A. K. The pharmacological potential of rutin. Saudi Pharm. J. 2017, Vol. 25, pp. 149–164. 12. Chand P., Kumar H., Jain R., Jain A., Jain V. Flavonoids as omnipotent candidates for cancer management. South African Journal of Botany. 2023, Vol. 158, pp. 334–346. 13. Rychlińska, I.; Gudej, J. Qualitative and quantitative chromatographic investigation of flavonoids in Pyrus communis L. flowers. Acta Pol. Pharm. 2003, Vol. 60, pp. 81–85. 14. Lee, Y. G.; Kim, W.; Cho, J.-Y.; Jeon, T.-I. Coumaroyl quinic acid derivatives and flavonoids from immature pear (Pyrus pyrifolia Nakai) fruit. Food Sci. Biotechnol. 2013, Vol. 22, pp. 803–810. 15. Williams, R. J.; Spencer, J. P. E.; Rice-Evans, C. Flavonoids: Antioxidants or signalling molecules? Free Radic. Biol. Med. 2004, Vol. 36, pp. 838–849. 16. Ganeshpurkar, A., & Saluja, A. K. Protective effect of rutin on humoral and cell mediated immunity in rat model. ChemicoBiological Interactions, 2017, Vol. 273, pp. 154–159. 17. Bahare Salehi, Alessandro Venditti, Mehdi Sharifi-Rad, Dorota Kregiel. The Therapeutic Potential of Apigenin. International Journal of Molecular Sciences. 2019, Vol. 20, pp. 1305.
Copyright (c) 2025 «ACTA NUUz»
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
.jpg)
1.png)
