ANALYSIS OF THE EFFECTS OF ETHANOL ON RATS THROUGH THE INTESTINAL HOMOGENATE USING AN EXPERIMENTAL MODEL OF ALCOHOLISM
This article presents the results of a study on the content of proteins, triglycerides, carbohydrates, and cholesterol in the small intestine homogenate of rats with experimentally induced chronic alcoholism under laboratory conditions. The obtained data were compared with those of healthy rats. When examining the physiological condition of rats exposed to ethanol, group formation behavior was observed, along with reduced body weight and physical activity. Hair loss and skin peeling were noted in certain areas of the body. Increased resistance and aggression were also observed.
1. Bellono N. W. et al. Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways //Cell. – 2017. – Т.
170. – №. 1. – С. 185-198.
2. Donaldson G. P., Lee S. M., Mazmanian S. K. Gut biogeography of the bacterial microbiota //Nature Reviews Microbiology.
– 2016. – Т. 14. – №. 1. – С. 20-32.
3. Corrêa‐Oliveira R. et al. Regulation of immune cell function by short‐chain fatty acids //Clinical & translational immunology.
– 2016. – Т. 5. – №. 4. – С. e73.
4. Feuerstein J. D., Cheifetz A. S. Crohn disease: epidemiology, diagnosis, and management //Mayo Clinic Proceedings. – Elsevier, 2017. – Т. 92. – №. 7. – С. 1088-1103..
5. Furness J. B. Integrated neural and endocrine control of gastrointestinal function //The Enteric Nervous System: 30 Years Later. – 2016. – С. 159-173.
6. Lieber C. S. Alcohol and the liver: 1994 update //Gastroenterology. – 2004. – Т. 106. – № 4. – С. 1085–1105.
7. Kim S. J., Kim M. C., Um J. Y., Hong S. H. The beneficial effect of anti-inflammatory function of ethanol extract from Artemisia iwayomogi in DSS-induced colitis //Mediators of Inflammation. – 2015. – Т. 2015. – Article ID: 454703.
8. Ma T. Y., Iwamoto G. K., Hoa N. T. et al. TNF-α-induced increase in intestinal epithelial tight junction permeability requires NF-κB activation //American Journal of Physiology-Gastrointestinal and Liver Physiology. – 2019. – Т. 286. – № 3. – С. G367–G376.
9. Zhao X., Sun L., Mu T., Liu Y., Wang X. Protective effects of polyphenols against chronic alcohol-induced liver injury in mice //Nutrition Research and Practice. – 2017. – Т. 11. – № 2. – С. 103–110.
10. Fukui H. Role of gut in alcohol-induced liver injury //Journal of Gastroenterology and Hepatology. – 2001. – Т. 16. – № 2. – С. 115–120.
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