THE CHARACTERISTICS OF THE FREQUENCY OF HLA-DRB POLYMORPHISM IN THE UZBEK POPULATION OF SAMARQAND REGION
The Samarkand region, as a center of historical ethnic intermixing, represents a unique area for genetic research. This study examined the distribution characteristics of HLA-DRB1, DRB3, DRB4, and DRB5 gene polymorphisms in the Uzbek population of the region. According to genotyping results, the HLA-DRB1*0101 allele was identified with the highest frequency (22.3%), standing out as the most prevalent form in the area. The presence of DRB3, DRB4, and DRB5 alleles plays an important role in shaping immune responses in transplantation, autoimmune, and infectious diseases. The findings not only highlight the genetic diversity of the region's population but also provide valuable information for practical use in medicine and clinical immunogenetics
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