ПРОГНОЗИРОВАНИЕ БИОЛОГИЧЕСКОЙ АКТИВНОСТИ 2-(ФЕНИЛМЕТИЛ)-1H-БЕНЗИМИДАЗОЛА
A comprehensive in silico study of 2-(phenylmethyl)-1H-benzimidazole (FAB), an organic compound with potential biological activity, was conducted in this work. Using the PASS Online web platform, the pharmacological properties and predicted mechanisms of action of the compound were assessed. The GUSAR program was employed to evaluate acute and environmental toxicity, including LD50 prediction models for rats and mice, as well as ecological parameters such as LD50 for Daphnia magna, Fathead minnow, Tetrahymena pyriformis, and the logarithmic bioconcentration factor (BCF). The results of PASS Online indicated that FAB may exhibit antibacterial, anti-inflammatory, and antioxidant activities, as well as inhibitory effects on various enzymes. These findings suggest the advisability of further investigation of FAB as a pharmacologically active compound, alongside parallel evaluation of its environmental safety.
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