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STEPWISE SYNTHESIS OF ENAMINONE DERIVATIVES

enaminones, homoveratrylamine, three-component condensation, imines, ethyl acetoacetate, aromatic aldehydes, organic synthesis.

Authors

In this study, new enaminone derivatives belonging to the class of 5-N-((3,4-dimethoxyphenethyl)amino)-2,4-diethyl ester-1methyl-3-phenylcyclohex-4-en-1-ol were synthesized via a three-component condensation reaction involving 3,4dimethoxyphenethylamine (homoveratrylamine), aromatic aldehydes, and ethyl acetoacetate. The reactions were carried out in a stepwise manner through intermediate imines. The structures of the synthesized compounds were confirmed by IR, ¹H NMR, and ¹³C NMR spectroscopic analysis.