STEPWISE SYNTHESIS OF ENAMINONE DERIVATIVES
In this study, new enaminone derivatives belonging to the class of 5-N-((3,4-dimethoxyphenethyl)amino)-2,4-diethyl ester-1methyl-3-phenylcyclohex-4-en-1-ol were synthesized via a three-component condensation reaction involving 3,4dimethoxyphenethylamine (homoveratrylamine), aromatic aldehydes, and ethyl acetoacetate. The reactions were carried out in a stepwise manner through intermediate imines. The structures of the synthesized compounds were confirmed by IR, ¹H NMR, and ¹³C NMR spectroscopic analysis.
1. Katrizky A.R., Ramsden C.A., Scriven E.F.V., Taylor R.J.K. Comprehensive Heterocyclic Chemistry III, Vol. 13, Elsevier, 2008 – pp. 45– 60.
2. Khusnutdinov R.I. et al. Synthesis and properties of β-enaminones. Russian Journal of Organic Chemistry, 2015, 51(9), pp. 1253–1264.
3. Abdel-Rahman R.M., El-Shafei A.K.H. Enaminones in heterocyclic synthesis: A review. Archiv der Pharmazie, 2014, 347(9), pp. 615–630.
4. Dandia A., Jain A. Enaminones as versatile synthons in organic synthesis. Tetrahedron, 2017, 73(4), pp. 512–539.
5. A.A. Khudoyberdiyeva et al. Three-component synthesis of enaminones based on homoveratrilamine and aromatic aldehydes. Central Asian Journal of Medical and Natural Sciences, 2024, 5(4), pp. 876–880.
6. A.A. Xudoyberdiyeva, Z.E. Urunbayev et al. Karbonil birikmalarning gomoveratrilamin bilan uch komponentli reaksiyalari asosida yenaminonlar sintezi. O‘zMU Ilmiy axborotnomasi, 2024, №3, 470–473 b.
7. A.A. Xudoyberdiyeva et al. Karbosikllanish reaksiyalari o‘rganilishi. SamDU Ilmiy axborotnomasi. 2024, №3, 120–125 b.
8. A.A. Xudoyberdiyeva et al. Sintez of enaminones via condensation reactions. Universum: Kimyo va Biologiya, 2024, №6, 40–45. 9. A.A. Khudoyberdiyeva et al. Synthesis and cytotoxicity of enaminones’ derivatives. Int. conf. “Actual Problems of the Chemistry of Natural Compounds”, 2024, Tashkent, p. 175.
10. A.A. Xudoyberdiyeva et al. Asetilaseton, gomoveratrilamin va ba’zi aromatik aldegidlar ishtirokidagi kondensatsiya reaksiyalari. NamDU Ilmiy axborotnoma, 2024, №7, 59–62 b.
11. A.A. Xudoyberdiyeva et al. O‘zaro ta’sirlashish reaksiyasi o‘rganilishi. “Tabiiy birikmalar kimyosi”, Toshkent, 2021, s. 296.
12. A.A. Xudoyberdiyeva et al. Innovator ayollar – 2024 forumi, Toshkent, 2024, s. 147–148.
13. A.A. Khudoyberdiyeva et al. Actual Problems of the Chemistry of Natural Compounds, 2023, Tashkent, p. 286.
14. A.A. Xudoyberdiyeva et al. Karbosikllanish reaksiyalari. Respublika konferensiyasi, Toshkent, 2024, s. 285. 15. A.A. Xudoyberdiyeva et al. Study of acetylacetone, homoveratrylamine and p-hydroxybenzaldehyde. Int. Conf., Tashkent, 2023, p. 286.
Copyright (c) 2025 «ACTA NUUz»

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.






.jpg)

1.png)





