THEORETICAL PRINCIPLES OF THE DEVELOPMENT OF PROBIOTIC SUPPLEMENTS AFFECTING THE BODY'S IMMUNOLOGICAL INDICATORS
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Decreased contact of the child with microorganisms in urbanized living conditions leads to defects in the formation of immune tolerance and an increase in the number of allergic and autoimmune diseases. Probiotics have a positive effect on the improvement of allergic diseases, especially children's eczema, and the reduction of bronchial asthma symptoms. The use of probiotics is physiological, they have the effect of stimulating the functional maturation of the immune system. The article states that probiotics stimulate innate and acquired immune responses, induce secretory and systemic IgA secretion, promote phagocytosis by altering T cell responses, maintain homeostasis of Th1 and Th2 activity by enhancing Th1 responses and dampening Th2 responses. analysis of many studies has been carried out.
Munira TEMIROVA, & Nilufar ELOVA. (2024). THEORETICAL PRINCIPLES OF THE DEVELOPMENT OF PROBIOTIC SUPPLEMENTS AFFECTING THE BODY’S IMMUNOLOGICAL INDICATORS. «ACTA NUUz», 3(3.1), 142–146. https://doi.org/10.69617/nuuz.v3i3.1.1746
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17. Maldonado Galdeano C., Cazorla S.I., Lemme Dumit J.M., Vélez E., Perdigón G. Beneficial Effects of Probiotic Consumption on the Immune System. Ann Nutr Metab. 2019;74(2):115–124. doi: 10.1159/000496426.
18. Famularo G., Moretti S., Marcellini S., De Simone C. Stimulation of immunity by probiotics. In: Fuller R. (ed.). Probiotics: therapeutic and other beneficial effects. Chapman and Hall, London; 1997.
19. Shah N.P. Functional cultures and health benefits. Int Dairy J. 2007;17(11):1262–1277. doi: 10.1016/j.idairyj.2007.01.014.
20. Guarner F., Malagelada J.R. Gut flora in health and disease. Lancet. 2003;361(9356):512–519. doi: 10.1016/S0140-6736(03)12489-0.
21. Clancy R. Immunobiotics and the probiotic evolution. FEMS Immunol Med Microbiol. 2003;38(1):9–12. doi: 10.1016/S0928-8244(03)00147-0.
22. Spanhaak S., Havenaar R., Schaafsma G. The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans. Eur J Clin Nutr. 1998;52:899–907. doi: 10.1038/sj.ejcn.1600663.
23. Ezendam J., DeKlerk A., Gremmer E.R., van Loveren H. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008;154(3):424–431. doi: 10.1111/j.1365-2249.2008.03788.x.
24. Хорошилова Н. В. Иммуномодулирующее и лечебное действие бифидо- и лактобактерий у детей с аллергическими заболеваниями и частыми респираторными инфекциями. Вопр. совр. педиатрии. 2013; 12 (5): 86-90.
2. Fernandez L et al. The human milk microbiota: Origin and potential roles in health and disease. Pharmacol Res 2013; 69: 1–10.
3. Bouskra D, Brezillon C, Berard M et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 2008; 456: 507–10.
4. Rook GA, Martinelli R, Brunet LR. Innate immune responses to mycobacteria and the downregulation of atopic responses. Curr. Opin Allergy Clin Immunol 2003; 3 (5): 337–42.
5. Okada H, Kuhn C, Feillet H, Bach J-F. The «hygiene hypothesis» for autoimmune and allergic diseases: an update. Clin Exp Immunol. 2010; 160 (1): 1–9.
6. Sekirov I, Russell SL, Antunes LCM, Finlay BB. Gut Microbiota in Health and Disease. Physiol Rev 2010; 90: 859–904.
7. Mohseni MJ, Aryan Z, Emamzadeh-Fard S et al. Combination of probiotics and antibiotics in the prevention of recurrent urinary tract infection in children. Iran J Pediatr 2013; 23 (4):430–8.
8. Del Giudice MM, Leonardi S, Ciprandi G et al. Probiotics in childhood: allergic illness and respiratory infections. J Clin Gastroenterol. 2012; 46: 69–72.
9. Probiotics and prebiotics. Practice Guideline World Gastroenterology Organisation 2008; http://www.worldgastroenterology.org/assets/downloads/en/pdf/guidelines/19_probiotics_prebiotics.pdf
10. С.В.Ильина. Пробиотики как иммуномодуляторы и их место в профилактике рецидивирующих инфекций дыхательных путей у детей// Педиатрия. №3. 2014. приложение consilium medicum. С. 2-33.
11. Maynard C.L., Elson C.O., Hatton R.D., Weaver C.T. Reciprocal interactions of the intestinal microbiota and immune system. Nature. 2012;489(7415):231–241. doi: 10.1038/nature11551.
12. Collins S.M., Surette M., Bercik P. The interplay between the intestinal microbiota and the brain. Nat Rev Microbiol. 2012;10(11):735–742. doi: 10.1038/nrmicro2876.
13. Goto Y., Ivanov I.I. Intestinal epithelial cells as mediators of the commensal-host immune crosstalk. Immunol Cell Biol. 2013;91(3):204–214. doi: 10.1038/icb.2012.80
14. Lavelle E.C., Murphy C., O’Neill L.A.J., Creagh E.M. The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis. Mucosal Immunol. 2010;3(1):17–28. doi: 10.1038/mi.2009.124
15. Kamada N., Seo S., Chen G., Núñez G. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol. 2013;13(5):321–335. doi: 10.1038/nri3430
16. Hill C., Guarner F., Reid G., Gibson G.R., Merenstein D.J., Pot B. et al. The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11:506–514. doi: 10.1038/nrgastro.2014.66.
17. Maldonado Galdeano C., Cazorla S.I., Lemme Dumit J.M., Vélez E., Perdigón G. Beneficial Effects of Probiotic Consumption on the Immune System. Ann Nutr Metab. 2019;74(2):115–124. doi: 10.1159/000496426.
18. Famularo G., Moretti S., Marcellini S., De Simone C. Stimulation of immunity by probiotics. In: Fuller R. (ed.). Probiotics: therapeutic and other beneficial effects. Chapman and Hall, London; 1997.
19. Shah N.P. Functional cultures and health benefits. Int Dairy J. 2007;17(11):1262–1277. doi: 10.1016/j.idairyj.2007.01.014.
20. Guarner F., Malagelada J.R. Gut flora in health and disease. Lancet. 2003;361(9356):512–519. doi: 10.1016/S0140-6736(03)12489-0.
21. Clancy R. Immunobiotics and the probiotic evolution. FEMS Immunol Med Microbiol. 2003;38(1):9–12. doi: 10.1016/S0928-8244(03)00147-0.
22. Spanhaak S., Havenaar R., Schaafsma G. The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans. Eur J Clin Nutr. 1998;52:899–907. doi: 10.1038/sj.ejcn.1600663.
23. Ezendam J., DeKlerk A., Gremmer E.R., van Loveren H. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008;154(3):424–431. doi: 10.1111/j.1365-2249.2008.03788.x.
24. Хорошилова Н. В. Иммуномодулирующее и лечебное действие бифидо- и лактобактерий у детей с аллергическими заболеваниями и частыми респираторными инфекциями. Вопр. совр. педиатрии. 2013; 12 (5): 86-90.
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