ORGANIZMNING IMMUNOLOGIK KO’RSATKICHLARIGA TA’SIR QILUVCHI PROBIOTIK QO’SHIMCHALAR ISHLAB CHIQISHNING NAZARIY ASOSLARI
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Bolaning urbanizatsiyalashgan yashash sharoitida mikroorganizmlar bilan aloqalasi kamayishi immun tolerantlikning shakllanishidagi noqisliklarga va allergik va autoimmun kasalliklar soni ortishiga olib keladi. Probiotiklar allergik kasalliklar, xususan, bolalar ekzemasining kechishiga va bronxial astma symptomlarining kamayishiga ijobiy ta`sir ko`rsatadi. Probiotiklardan foydalanish fiziologik bo`lib, ular immun tizimining funktsional yetilishini stimulyatsiyalash ta’siriga ega. Maqolada probiotiklar tug'ma va orttirilgan immunitet reaktsiyasini rag'batlantirishi, sekretor va tizimli IgA sekretsiyasini qo'zg'atishi, T hujayralari javoblarini o'zgartirish orqali fagotsitozni rag'batlantirishi, Th1 javoblarini kuchaytirish va Th2 javoblarini susaytirish orqali Th1 va Th2 faolligining gomeostazini saqlab turishini ko'rsatadigan ko'plab tadqiqotlar tahlili amalga oshirilgan.
Munira TEMIROVA, & Nilufar ELOVA. (2024). ORGANIZMNING IMMUNOLOGIK KO’RSATKICHLARIGA TA’SIR QILUVCHI PROBIOTIK QO’SHIMCHALAR ISHLAB CHIQISHNING NAZARIY ASOSLARI. «O‘zMU XABARLARI», 3(3.1), 142–146. https://doi.org/10.69617/nuuz.v3i3.1.1746
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2. Fernandez L et al. The human milk microbiota: Origin and potential roles in health and disease. Pharmacol Res 2013; 69: 1–10.
3. Bouskra D, Brezillon C, Berard M et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 2008; 456: 507–10.
4. Rook GA, Martinelli R, Brunet LR. Innate immune responses to mycobacteria and the downregulation of atopic responses. Curr. Opin Allergy Clin Immunol 2003; 3 (5): 337–42.
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7. Mohseni MJ, Aryan Z, Emamzadeh-Fard S et al. Combination of probiotics and antibiotics in the prevention of recurrent urinary tract infection in children. Iran J Pediatr 2013; 23 (4):430–8.
8. Del Giudice MM, Leonardi S, Ciprandi G et al. Probiotics in childhood: allergic illness and respiratory infections. J Clin Gastroenterol. 2012; 46: 69–72.
9. Probiotics and prebiotics. Practice Guideline World Gastroenterology Organisation 2008; http://www.worldgastroenterology.org/assets/downloads/en/pdf/guidelines/19_probiotics_prebiotics.pdf
10. С.В.Ильина. Пробиотики как иммуномодуляторы и их место в профилактике рецидивирующих инфекций дыхательных путей у детей// Педиатрия. №3. 2014. приложение consilium medicum. С. 2-33.
11. Maynard C.L., Elson C.O., Hatton R.D., Weaver C.T. Reciprocal interactions of the intestinal microbiota and immune system. Nature. 2012;489(7415):231–241. doi: 10.1038/nature11551.
12. Collins S.M., Surette M., Bercik P. The interplay between the intestinal microbiota and the brain. Nat Rev Microbiol. 2012;10(11):735–742. doi: 10.1038/nrmicro2876.
13. Goto Y., Ivanov I.I. Intestinal epithelial cells as mediators of the commensal-host immune crosstalk. Immunol Cell Biol. 2013;91(3):204–214. doi: 10.1038/icb.2012.80
14. Lavelle E.C., Murphy C., O’Neill L.A.J., Creagh E.M. The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis. Mucosal Immunol. 2010;3(1):17–28. doi: 10.1038/mi.2009.124
15. Kamada N., Seo S., Chen G., Núñez G. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol. 2013;13(5):321–335. doi: 10.1038/nri3430
16. Hill C., Guarner F., Reid G., Gibson G.R., Merenstein D.J., Pot B. et al. The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11:506–514. doi: 10.1038/nrgastro.2014.66.
17. Maldonado Galdeano C., Cazorla S.I., Lemme Dumit J.M., Vélez E., Perdigón G. Beneficial Effects of Probiotic Consumption on the Immune System. Ann Nutr Metab. 2019;74(2):115–124. doi: 10.1159/000496426.
18. Famularo G., Moretti S., Marcellini S., De Simone C. Stimulation of immunity by probiotics. In: Fuller R. (ed.). Probiotics: therapeutic and other beneficial effects. Chapman and Hall, London; 1997.
19. Shah N.P. Functional cultures and health benefits. Int Dairy J. 2007;17(11):1262–1277. doi: 10.1016/j.idairyj.2007.01.014.
20. Guarner F., Malagelada J.R. Gut flora in health and disease. Lancet. 2003;361(9356):512–519. doi: 10.1016/S0140-6736(03)12489-0.
21. Clancy R. Immunobiotics and the probiotic evolution. FEMS Immunol Med Microbiol. 2003;38(1):9–12. doi: 10.1016/S0928-8244(03)00147-0.
22. Spanhaak S., Havenaar R., Schaafsma G. The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans. Eur J Clin Nutr. 1998;52:899–907. doi: 10.1038/sj.ejcn.1600663.
23. Ezendam J., DeKlerk A., Gremmer E.R., van Loveren H. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008;154(3):424–431. doi: 10.1111/j.1365-2249.2008.03788.x.
24. Хорошилова Н. В. Иммуномодулирующее и лечебное действие бифидо- и лактобактерий у детей с аллергическими заболеваниями и частыми респираторными инфекциями. Вопр. совр. педиатрии. 2013; 12 (5): 86-90.
2. Fernandez L et al. The human milk microbiota: Origin and potential roles in health and disease. Pharmacol Res 2013; 69: 1–10.
3. Bouskra D, Brezillon C, Berard M et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 2008; 456: 507–10.
4. Rook GA, Martinelli R, Brunet LR. Innate immune responses to mycobacteria and the downregulation of atopic responses. Curr. Opin Allergy Clin Immunol 2003; 3 (5): 337–42.
5. Okada H, Kuhn C, Feillet H, Bach J-F. The «hygiene hypothesis» for autoimmune and allergic diseases: an update. Clin Exp Immunol. 2010; 160 (1): 1–9.
6. Sekirov I, Russell SL, Antunes LCM, Finlay BB. Gut Microbiota in Health and Disease. Physiol Rev 2010; 90: 859–904.
7. Mohseni MJ, Aryan Z, Emamzadeh-Fard S et al. Combination of probiotics and antibiotics in the prevention of recurrent urinary tract infection in children. Iran J Pediatr 2013; 23 (4):430–8.
8. Del Giudice MM, Leonardi S, Ciprandi G et al. Probiotics in childhood: allergic illness and respiratory infections. J Clin Gastroenterol. 2012; 46: 69–72.
9. Probiotics and prebiotics. Practice Guideline World Gastroenterology Organisation 2008; http://www.worldgastroenterology.org/assets/downloads/en/pdf/guidelines/19_probiotics_prebiotics.pdf
10. С.В.Ильина. Пробиотики как иммуномодуляторы и их место в профилактике рецидивирующих инфекций дыхательных путей у детей// Педиатрия. №3. 2014. приложение consilium medicum. С. 2-33.
11. Maynard C.L., Elson C.O., Hatton R.D., Weaver C.T. Reciprocal interactions of the intestinal microbiota and immune system. Nature. 2012;489(7415):231–241. doi: 10.1038/nature11551.
12. Collins S.M., Surette M., Bercik P. The interplay between the intestinal microbiota and the brain. Nat Rev Microbiol. 2012;10(11):735–742. doi: 10.1038/nrmicro2876.
13. Goto Y., Ivanov I.I. Intestinal epithelial cells as mediators of the commensal-host immune crosstalk. Immunol Cell Biol. 2013;91(3):204–214. doi: 10.1038/icb.2012.80
14. Lavelle E.C., Murphy C., O’Neill L.A.J., Creagh E.M. The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis. Mucosal Immunol. 2010;3(1):17–28. doi: 10.1038/mi.2009.124
15. Kamada N., Seo S., Chen G., Núñez G. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol. 2013;13(5):321–335. doi: 10.1038/nri3430
16. Hill C., Guarner F., Reid G., Gibson G.R., Merenstein D.J., Pot B. et al. The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11:506–514. doi: 10.1038/nrgastro.2014.66.
17. Maldonado Galdeano C., Cazorla S.I., Lemme Dumit J.M., Vélez E., Perdigón G. Beneficial Effects of Probiotic Consumption on the Immune System. Ann Nutr Metab. 2019;74(2):115–124. doi: 10.1159/000496426.
18. Famularo G., Moretti S., Marcellini S., De Simone C. Stimulation of immunity by probiotics. In: Fuller R. (ed.). Probiotics: therapeutic and other beneficial effects. Chapman and Hall, London; 1997.
19. Shah N.P. Functional cultures and health benefits. Int Dairy J. 2007;17(11):1262–1277. doi: 10.1016/j.idairyj.2007.01.014.
20. Guarner F., Malagelada J.R. Gut flora in health and disease. Lancet. 2003;361(9356):512–519. doi: 10.1016/S0140-6736(03)12489-0.
21. Clancy R. Immunobiotics and the probiotic evolution. FEMS Immunol Med Microbiol. 2003;38(1):9–12. doi: 10.1016/S0928-8244(03)00147-0.
22. Spanhaak S., Havenaar R., Schaafsma G. The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans. Eur J Clin Nutr. 1998;52:899–907. doi: 10.1038/sj.ejcn.1600663.
23. Ezendam J., DeKlerk A., Gremmer E.R., van Loveren H. Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol. 2008;154(3):424–431. doi: 10.1111/j.1365-2249.2008.03788.x.
24. Хорошилова Н. В. Иммуномодулирующее и лечебное действие бифидо- и лактобактерий у детей с аллергическими заболеваниями и частыми респираторными инфекциями. Вопр. совр. педиатрии. 2013; 12 (5): 86-90.
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