EFFECT OF AUTOIMMUNE HYPOTHERIOSIS ON SMALL INTESTINAL ENZYMES AND ABSORPTION
In experimental autoimmune thyroiditis, rat’s body and small intestine weight increases, while hydrolysis and absorption of carbohydrates in the small intestine decrease. Chronic administration of selenium (0.4 mg/kg) to animals with autoimmune thyroiditis partially restores morphometric and small intestinal enzymatic and transport processes in the intestine.
1. Cuan-Baltazar Y., Soto-Vega E., Microorganisms associated to thyroid autoimmunity. Autoimmun. Rev. // 2020.19. P. 102126.
2. Vanderpump M.P. The epidemiology of thyroid disease, Br, Med, Bull // 2011. 99. P. 39–51, doi: 10,1093/bmb/ldr030.
3. Noto H., Mitsuhashi T., Ishibashi S., Kimura S., Hyperthyroidism presenting as dysphagia. Intern Med. // 2000. 39. P. 472473.
4. Abboud B., Sayegh R., Medlej R., Halaby G., Saade C., Farah P. A rare manifestation of hypothyroidism: intestinal obstruction, Report of 2 cases and review of the literature. J Med Liban. // 1999. 47. P. 364-366.
5. Bonapace E.S., Srinivasan R. Simultaneous occurrence of inflammatory bowel disease and thyroid disease. Am. J. Gastroenterol. // 2001. 96. P. 1925-1926.
6. Wegener M., Wedmann B., Langhoff T., Schaffstein J., Adamek R., Effect of hyperthyroidism on the transit of a caloric solid-liquid meal through the stomach, the small intestine, and the colon in man. J. Clin. Endocrinol Metab. // 1992.75. P. 745-749.
7. Laukkarinen J., Koobi P., Kalliovalkama J., Sand J., Mattila J., Turjanmaa V., Porsti I., Nordback I. Bile flow to the duodenum is reduced in hypothyreosis and enhanced in hyperthyreosis. Neurogastroenterol Motil. // 2002. 14. P. 183-188.
8. Захарова С.М., Савельева Л.В., Фадеева М.И. Ожирение и гипотиреоз ФГБУ Эндокринологический научный центр Минздрава РФ. Москва.
9. Масса тела и гипотиреоз - Ильинская больница Ильинская больница https://ihospital,ru › massa_tela_i_gipotire
10. Martin G.R., Henning S.J. Relative importance of corticosterone and thyroxine in the postnatal development of sucrase and maltase in rat small intestine. Endocrinology. // 1982. 3. P. 912-918.
11. Richard A., Hodin Sh. Thyroid Hormone Differentially Regulates Rat Intestinal Brush Border Enzyme Gene Expression Chamberlain. // 2002. 14. P. 183-188.
12. Ying Z., Yaling L., Xiaoqin G., Zhen L. The correlation between selenium levels and autoimmune thyroid disease: a systematic review and meta-analysis. // Annals of Palliative Medicine // 2021. Vol 10, No 4.
13. Zhang, J.; Saad, R.; Taylor, E.W.; Rayman, M.P. Selenium and selenoproteins in viral infection with potential relevance to COVID-19. Redox Biol. // 2020. 37. P. 101-127. [Google Scholar] [CrossRef] [PubMed].
14. Kieliszek, M.; Lipinski, B. Selenium supplementation in the prevention of coronavirus infections (COVID-19). Med. Hypotheses // 2020. 143. P. 109-878.
15. Трошина Е.А., Сенюшкина Е.С., Терехова М.А. Роль селена в патогенезе заболеваний щитовидной железы. Клиническая и экспериментальная тиреоидология. // 2018.14.(4). P. 192-205.
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