EFFECT OF POLYPHENOLIC COMPOUNDS YaN-1 AND YaN-2 ON THE ATP-SENSITIVE POTASSIUM CHANNEL OF HEART MITOCHONDRIA IN EXPERIMENTAL MYOCARDITIS
This article studies the effect of diazoimine derivatives of gossypol polyphenols YaN-1 and YaN-2 on the activity of the ATP-dependent potassium channel (mitoKATP channel) of rat heart mitochondria in experimental myocarditis induced by adrenaline. The activity of the mitoKATP channel of the inner mitochondrial membrane was determined by measuring the change in optical density on a spectrophotometer. Male white outbred rats taken for the experiment were divided into V groups. To induce myocarditis, rats were injected subcutaneously (per. os) with 0.1% adrenaline solution per 100 g of body weight for 7 days. For the experiments, rats of group III with myocarditis were administered polyphenol YaN-1 (20 mg/kg/day), group IV YaN-2 (10 mg/kg/day) and group V flavonoid quercetin (20 mg/kg/day) for 10 days orally. Under the conditions of adrenaline myocarditis, it was found that the diazamine derivative of gossypol YaN-2 had an activating effect on the activity of the cardiac mitoKATP channel, which was more active than YaN-1 and quercetin.
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