MIS(II) IONINING, SULFOMETAKSAZOL BILAN KOMPLEKS BIRIKMASI SINTEZI VA IQ-SPEKTROSKOPIYA TAHLILI
In this study, the synthesis methods of coordination complexes of sulfamethoxazole with Cu(II) salts were investigated, and their structures were examined using physicochemical analysis techniques. The structure of the synthesized complexes was analyzed through elemental analysis, SEM-EDX, and IR spectroscopy. Based on the IR spectroscopic data, the coordinating groups of the selected ligand and the shifting peaks of functional groups were examined to confirm the formation of coordination complexes. The results indicated that sulfamethoxazole predominantly acts as a bidentate ligand (and in some cases as a monodentate ligand) during coordination.
1. El-Sherif, A.A. va boshqalar. Synthesis, characterization and antimicrobial activity of metal complexes of sulfamethoxazole // Journal of Coordination Chemistry. 2010.
2. M. A. Salam et al. Spectroscopic and thermal studies of some metal complexes of sulfamethoxazole // Journal: Spectrochimica Acta Part A.
3. Napolitano. Transition metal complexes of sulfonamide drugs: coordination modes and biological activity // Journal: Coordination Chemistry Reviews. 2008
4. L.de L.Marques, E.S.Lang, H.Fenner, E.E.Castellano. Synthesis and Characterization of [Hg(sulfamethoxazolato)2]·2DMSO and [Cu2(μ-CH3CO2)4(sulfamethoxazole)2] // Zeitschrift fur Anorganische und Allgemeine Chemie, 2005, 631, P-745-748, DOI: 10.1002/zaac.200400443
5. Ai-Qiu Liao, Juan Wen, Jing-Chen Wei, Bing-Bing Xu, Nan Jin, Hong-Yu Lin, Xiu-Ying Qin. Syntheses, crystal structures of copper (II)-based complexes of sulfonamide derivatives and their anticancer effects through the synergistic effect of anti-angiogenesis, anti-inflammation, pro-apoptosis and cuproptosis // European Journal of Medicinal Chemistry, 2024, 280, 116954, DOI: 10.1016/j.ejmech.2024.116954
6. L.L.Marques, G.M.de Oliveira, E.S.Lang. Effects of Coordinating Solvents on the Supramolecular Assembling of Tectons arised from the Metallation of Sulfamethoxazole: Synthesis and Structural Characterization of Polymeric [Cd(sulfamethoxazolato)2(L)2]n {L = N,N-dimethylformamide (DMF); Dimethyl Sulfoxide (DMSO)} and [Cd(sulfamethoxazolato)2(Py)2]n·n(Py)(Py =pyridine) // Zeitschrift fur Anorganische und Allgemeine Chemie, 2006, 632, P-2310-2314. DOI: 10.1002/zaac.200600167
7. Shahnaz Rostamizadeh, Zahra Daneshfar, Hamid Moghimi. Synthesis of sulfamethoxazole and sulfabenzamide metal complexes; evaluation of their antibacterial activity // European Journal of Medicinal Chemistry 171 (2019)., P-364-371. https://doi.org/10.1016/j.ejmech.2019.03.002
8. Смит А. Прикладная ИК спектроскопия. М.: Мир, 1982. 328 с.
9. Преч Э. и др., Определение строения органических соединений (табл. спектральных данных) 2006. 441 с.
10. Беккера Ю. Спектроскопия. Техносфера, 2009. 528 с.
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