INVESTIGATION OF THE NEUROPROTECTIVE PROPERTIES OF KAEMPFEROL-3-O SOPHOROSIDE IN A CELLULAR MODEL OF PARKINSON'S DISEASE
We investigated the effects of kaempferol-3-O-sophoroside (PCS-1) on mitochondrial bioenergetic processes under normal conditions and in a cellular model of Parkinson’s disease. Treatment with PCS-1 led to an increase in mitochondrial membrane potential (ΨM) both under physiological conditions and in the Parkinson’s model. It was found that PCS-1 reduces the activity of respiratory chain complex I and also decreases the contribution of F₁F₀ ATP synthase to the maintenance of ΨM in the Parkinson’s disease model.
1. Althaher A.R., Alwahsh M. (2023) An overview of ATP synthase, inhibitors, and their toxicity. Heliyon 9(11): e22459. DOI: 10.1016/j.heliyon.2023.e22459
2. Lagoa R. et.al. (2011) Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria. Biochim Biophys Acta 1807(12): 1562-1572. DOI: 10.1016/j.bbabio.2011.09.022
3. Небесная К.С. и др. (2024) β экдистерон оказывает положительное влияние на биоэнергетику нейронов и астроцитов при ротеноновой модели болезни Паркинсона. Узбекский биологический журнал 4: 3-8.
4. Acin-Perez R. et.al. (2023) Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies. EMBO J 42(10): e111699. DOI: 10.15252/embj.2022111699
5. Connolly N.M.C. et.al (2018) Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death Differ 25(3): 542-572. DOI: 10.1038/s41418-017-0020-4
6. Hernansanz-Agustin P.et.al. (2020) Na(+) controls hypoxic signalling by the mitochondrial respiratory chain. Nature 586(7828): 287-291. DOI: 10.1038/s41586-020-2551-y
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