KEMPFEROL-3-O SOFOROZIDINING NEYROPROTEKTOR XUSUSIYATLARINI PARKINSON KASALLIGI HUJAYRA MODELIDA TADQIQ QILISH
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Mazkur tadqiqot ishida kempferol-3-O-soforozidning (PCS-1) normal fiziologik holatdagi va Parkinson kasalligi imitatsiya qilingan hujayralarda mitoxondriya bioenergetik jarayonlariga ta’siri o‘rganildi. Hujayralarga PCS-1 ta’sir ettirilganda har ikkala guruhdagi hujayralarning mitoxondrial membrana potensiali (ΨM) oshishi kuzatildi. PCS-1 mitoxondriya nafas zanjiri I kompleksi faolligini pasaytirishi, shuningdek, Parkinson kasalligi modelida ΨM shakllanishida F1FO ATF sintazaning hissasini kamaytirishi aniqlandi.
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