АНАЛИЗ КВАНТОВО-ХИМИЧЕСКИХ И ИК-СПЕКТРОВ КООРДИНАЦИОННЫХ СОЕДИНЕНИЙ СОЛИ Cu(II), Cd(II), Co(II) С 2-АМИНОБЕНЗОКСАЗОЛОМ
По результатам анализа научной литературы мало информации о комплексах металлов с 2-аминобензоксазолом и их
свойствах. Разработаны методы синтеза металлокомплексов ацетатов Cu(II), Cd(II) и Co(II) с 2-аминобензоксазолом и с
их помощью синтезированы металлокомплексы. Состав, структура синтезированных комплексных соединений
современными физико-химическими методами; анализировали с помощью элементного анализа, ИК-
спектроскопического анализа. Установлено, что лиганд 2-аминобензоксазол координируется через атом азота в
бензоксазольном кольце в ходе реакций комплексообразования.
1. Sharma J., Mishra P., Bhadoria J. 2-aminophenol as a leading reactant for the one pot synthetic strategies towards
benzoxazole derivatives // Results in Chemistry. -2022. -V. 4. ISSN 2211-7156 10.1016/j.rechem.2022.100670.
2. Arulmurugan S., Kavitha H.P., Vennila J.P. Review on the Synthetic Methods of Biologically Potent Benzoxazole
Derivatives //Mini-Reviews in Organic Chemistry. – 2021. – V. 18. – I. 6. – P. 769-785.
3. Osmaniye D. et al. Synthesis of some new benzoxazole derivatives and investigation of their anticancer activities
//European Journal of Medicinal Chemistry. – 2021. – V. 210. – P. 112979. doi.org/10.1016/j.ejmech.2020.112979.
4. Muhammed M. T. et al. Synthesis, antimicrobial activity, and molecular modeling studies of some benzoxazole derivatives
//Letters in Drug Design & Discovery. – 2022. – V. 19. – I. 8. – P. 757-768. 10.2174/1570180819666220408133643.
5. Liu K. G. et al. Identification of a series of benzoxazoles as potent 5-HT6 ligands //Bioorganic & Medicinal Chemistry
Letters. – 2009. – V. 19. – I. 4. – P. 1115-1117. 10.1016/j.bmcl.2008.12.107.
6. Chen S. C. et al. Mild direct amination of benzoxazoles using interpenetrating Cobalt (II)-based metal-organic framework
as an efficient heterogeneous catalyst //Molecular Catalysis. – 2018. – V. 450. – P. 104-111.10.1016/j.mcat.2018.03.011.
7. Cox C. D. et al. Discovery of the dual orexin receptor antagonist [(7 R)-4-(5-chloro-1, 3-benzoxazol-2-yl)-7-methyl-1, 4-
diazepan-1-yl][5-methyl-2-(2 H-1, 2, 3-triazol-2-yl) phenyl] methanone (MK-4305) for the treatment of insomnia //Journal
of medicinal chemistry. – 2010. – V. 53. – I. 14. – P. 5320-5332. 10.1021/jm100541c..
8. Frutos R. P. et al. Development of a Practical Process for the Synthesis of PDE4 Inhibitors //Organic Process Research &
Development. – 2016. – V. 20. – I. 5. – P. 982-988. 10.1021/acs.oprd.6b00104.
9. Neyts J. et al. Structure− activity relationship of new anti-Hepatitis C virus agents: Heterobicycle− coumarin conjugates
//Journal of medicinal chemistry. – 2009. – V. 52. – I. 5. – P. 1486-1490. 10.1021/jm801240d.
10. Odame F. et al. A new synthetic method for tetraazatricyclic derivatives and evaluation of their biological properties
//ChemistrySelect. – 2018. – V. 3. – I. 48. – P. 13613-13618. 10.1002/slct.201802930.
11. Šlachtová V., Chasák J., Brulíková L. Synthesis of Various 2-Aminobenzoxazoles: The Study of Cyclization and Smiles
Rearrangement //ACS omega. – 2019. – V. 4. – I. 21. – P. 19314-19323. 10.1021/acsomega.9b02702.
12. Potashman M.H. et al. Design, synthesis, and evaluation of orally active benzimidazoles and benzoxazoles as vascular
endothelial growth factor-2 receptor tyrosine kinase inhibitors //Journal of medicinal chemistry. – 2007. – V. 50. – I. 18. –
P. 4351-4373. 10.1021/jm070034i.
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