ОЦЕНКА ПРОТИВОДИАБЕТИЧЕСКОЙ И ПРОТИВОВОСПАЛИТЕЛЬНОЙ АКТИВНОСТИ НЕКОТОРЫХ ЛЕКАРСТВЕННЫХ РАСТЕНИЙ
Загрузки
Исследованы возможности использования местных растений с неизвестными лечебными свойствами в качестве ингибиторов α-амилазы поджелудочной железы. Среди 8 отобранных растений установлено, что концентрация 100 мг/мл этанольных экстрактов ладана, ромашки и бархатцев (80%, 77% и 72% в соответствующем росте) обладает высокой ингибирующей активностью. Доказано, что противовоспалительные свойства препаратов, используемых при лечении диабета, являются эффективным средством снижения осложнений, связанных с диабетом. Соответственно, были изучены противовоспалительные свойства этанольных экстрактов ладана, ромашки и бархатцев. Экстракты этих растений стабилизировали мембрану эритроцитов, вызванную нагреванием. Ладан показал 82%, ромашка 79% и лаванда 85% противовоспалительной активности. Соответственно, экстракты этих растений перспективны при лечении диабета 2 типа.
Iqbol MUXAMMEDOV, Muhayyoxon MAHAMMADJONOVA, Muxlisa ABDULATIBOVA, Sarvinoz TURDIMUHAMMADOVA, & Munisa MIRODILOVA. (2024). ОЦЕНКА ПРОТИВОДИАБЕТИЧЕСКОЙ И ПРОТИВОВОСПАЛИТЕЛЬНОЙ АКТИВНОСТИ НЕКОТОРЫХ ЛЕКАРСТВЕННЫХ РАСТЕНИЙ. «ВЕСТНИК НУУз», 3(3.1), 78–81. https://doi.org/10.69617/nuuz.v3i3.1.1717
1. Wild S, Roglic G, Green A, Sicree R & King H. (2004). Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care, 27, 5, (May 2004), 1047
2. M. A. Bhutkar and S. B. Bhise. In vitro assay of alpha amylase ingibitory activity of some indigenous plants. Int. J. Chem. Sci.: 10(1), 2012, P. 457-462.
3. Mostafa Selfayan and Foroogh Namjooyan. Ingibitory effect of Capparis spinosa extract on pancreatic alpha-amylase activity. Zahedan J Res Med Sci. 2016; 18(4):e6450. P. 1-4
4. Marilyn L Barrett, Jay K Udani. A proprietary alpha-amylase ingibitor from white bean (Phaseolus vulgaris): A review of clinical studies on weight loss and glycemic control. Barrett and Udani Nutrition Journal 2011,10:24, P. 1-10.
5. Young-In Kwon, Emmanouil Apostolidis and Kalidas Shetty. Ingibitory potential of wine and tea against a-amylase and a-glucosidase for management of hyperglycemia linked to type 2 diabetes. Journal of Food Biochemistry 32 (2008) P. 15-31.
6. Twinkle S. Bansode and B. K. Salalkar. Exploiting the therapeutic potential of secondary metabolites from Salvadora persica for diabetes using in silico and in vitro approach. Journal of Life Science and Biotechnology ISSN: 2456-1061, 2016, 5, P. 127-136.
7. Ali S. Alqahtani, Syed Hidayathulla, Md Tabish Rehman, Ali A. ElGamal, Shaza Al-Massarani, Valentina Razmovski-Naumovski, Mohammed S. Alqahtani, Rabab A. El Dib and Mohamed F. AlAjmi. Alpha-amylase and alpha-glucosidase enzyme ingibition and antioxidant potential of 3-oxolupenal and katononic acid isolated from Nuxia oppositifolia. Biomolecules 2020, 10, 61; doi:10.3390/biom10010061, P. 1-19.
8. Gladis Raja Malar Chelladurai, Chellaram Chinnachamy. Alpha amylase and Alpha glucosidase ingibitory effects of aqueous stem extract of Salacia oblonga and its GC-MS analysis. Brazilian Journal of Pharmaceutical Sciences 2018;54(1):e17151 P. 1-10
9. Nidal Jaradat, Nawaf Al-Maharik. Fingerprinting, Antimicrobial, Antioxidant, Anticancer, Cyclooxygenase and Metabolic Enzymes Ingibitory Characteristic Evaluations of Stachys viticina Boiss. Essential Oil. Molecules 2019, 24, 3880, P. 1-14.
10. Agger J. W., Eijsink V. G. H., Horn S. J. On the Determination of Water Content in Biomass Processing. BioEnergy Research. 2014, 7(1) pp 442–449
11. Hazalin N.A., Ramasamy K., Lim S.M., Wahab I.A., Cole A.Lj., Majeed A.A. Cytotoxic and antibacterial activities of endophytic fungi isolated from plants at the National Park, Pahang, Malaysia. BMC Complementary and alternative medicine. 2009, 9, P. 46
12. Picot C.M.N., Subratty H., Mahomoodally F. Inhibitory potential of five native antidiabetic medicinal plants on α-amylase, α-glucosidase, glucose entrapment, and amylosysis kinetics in vitro. Adv. Pharm. Sci., 2014, pp. 1-7.
13. Sakat S, Juvekar AR, Gambhire MN. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. Int J Pharm Pharm Sci 2010;2:146-55.
14. Sadique J, Al-Rqobahs WA, Bughaith, EI Gindi AR. The bioactivity of certain medicinal plants on the stabilization of RBS membrane system. Fitoterapia 1989;60:525-32.
15. Sakat S, Juvekar AR, Gambhire MN. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. Int J Pharm Pharm Sci 2010;2:146-55.
16. Shinde UA, Kulkarni KR, Phadke AS, Nair AM, Mungantiwar AA, Dikshit VJ, et al. Mast cell stabilizing and lipoxygenase inhibitory activity of Cedrus deodara (Roxb.) loud. Wood oil. Indian J Exp Biol 1999;37:258-61
17. Selfayan M., Namjooyan F. Ingibitory effect of Capparis spinosa extract on pancreatic alpha-amylase activity. Zahedan J Res Med Sci., 2016; 18(4), pp. 1-4.
18. Sameer H., Nayer M. Evaluation of some biological activities of Trigonella hamosa aerial parts. Journal of Pharmacognosy and Phytotherapy., 2017, 9(11), pp. 165-172
19. Somnath De., Chandra D., Mandal T. In vitro anti-inflammatory and anti-diabetic activity of methanolic extract of Cardanthera difformis druce. International Research Journal Of Pharmacy., 2016, 7 (12), pp. 56-60
20. Twinkle S., Bansode B., Salalkar K. Exploiting the therapeutic potential of secondary metabolites from Salvadora persica for diabetes using in silico and in vitro approach. Journal of Life Science and Biotechnology., 2016, 5, pp. 127-136.
2. M. A. Bhutkar and S. B. Bhise. In vitro assay of alpha amylase ingibitory activity of some indigenous plants. Int. J. Chem. Sci.: 10(1), 2012, P. 457-462.
3. Mostafa Selfayan and Foroogh Namjooyan. Ingibitory effect of Capparis spinosa extract on pancreatic alpha-amylase activity. Zahedan J Res Med Sci. 2016; 18(4):e6450. P. 1-4
4. Marilyn L Barrett, Jay K Udani. A proprietary alpha-amylase ingibitor from white bean (Phaseolus vulgaris): A review of clinical studies on weight loss and glycemic control. Barrett and Udani Nutrition Journal 2011,10:24, P. 1-10.
5. Young-In Kwon, Emmanouil Apostolidis and Kalidas Shetty. Ingibitory potential of wine and tea against a-amylase and a-glucosidase for management of hyperglycemia linked to type 2 diabetes. Journal of Food Biochemistry 32 (2008) P. 15-31.
6. Twinkle S. Bansode and B. K. Salalkar. Exploiting the therapeutic potential of secondary metabolites from Salvadora persica for diabetes using in silico and in vitro approach. Journal of Life Science and Biotechnology ISSN: 2456-1061, 2016, 5, P. 127-136.
7. Ali S. Alqahtani, Syed Hidayathulla, Md Tabish Rehman, Ali A. ElGamal, Shaza Al-Massarani, Valentina Razmovski-Naumovski, Mohammed S. Alqahtani, Rabab A. El Dib and Mohamed F. AlAjmi. Alpha-amylase and alpha-glucosidase enzyme ingibition and antioxidant potential of 3-oxolupenal and katononic acid isolated from Nuxia oppositifolia. Biomolecules 2020, 10, 61; doi:10.3390/biom10010061, P. 1-19.
8. Gladis Raja Malar Chelladurai, Chellaram Chinnachamy. Alpha amylase and Alpha glucosidase ingibitory effects of aqueous stem extract of Salacia oblonga and its GC-MS analysis. Brazilian Journal of Pharmaceutical Sciences 2018;54(1):e17151 P. 1-10
9. Nidal Jaradat, Nawaf Al-Maharik. Fingerprinting, Antimicrobial, Antioxidant, Anticancer, Cyclooxygenase and Metabolic Enzymes Ingibitory Characteristic Evaluations of Stachys viticina Boiss. Essential Oil. Molecules 2019, 24, 3880, P. 1-14.
10. Agger J. W., Eijsink V. G. H., Horn S. J. On the Determination of Water Content in Biomass Processing. BioEnergy Research. 2014, 7(1) pp 442–449
11. Hazalin N.A., Ramasamy K., Lim S.M., Wahab I.A., Cole A.Lj., Majeed A.A. Cytotoxic and antibacterial activities of endophytic fungi isolated from plants at the National Park, Pahang, Malaysia. BMC Complementary and alternative medicine. 2009, 9, P. 46
12. Picot C.M.N., Subratty H., Mahomoodally F. Inhibitory potential of five native antidiabetic medicinal plants on α-amylase, α-glucosidase, glucose entrapment, and amylosysis kinetics in vitro. Adv. Pharm. Sci., 2014, pp. 1-7.
13. Sakat S, Juvekar AR, Gambhire MN. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. Int J Pharm Pharm Sci 2010;2:146-55.
14. Sadique J, Al-Rqobahs WA, Bughaith, EI Gindi AR. The bioactivity of certain medicinal plants on the stabilization of RBS membrane system. Fitoterapia 1989;60:525-32.
15. Sakat S, Juvekar AR, Gambhire MN. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. Int J Pharm Pharm Sci 2010;2:146-55.
16. Shinde UA, Kulkarni KR, Phadke AS, Nair AM, Mungantiwar AA, Dikshit VJ, et al. Mast cell stabilizing and lipoxygenase inhibitory activity of Cedrus deodara (Roxb.) loud. Wood oil. Indian J Exp Biol 1999;37:258-61
17. Selfayan M., Namjooyan F. Ingibitory effect of Capparis spinosa extract on pancreatic alpha-amylase activity. Zahedan J Res Med Sci., 2016; 18(4), pp. 1-4.
18. Sameer H., Nayer M. Evaluation of some biological activities of Trigonella hamosa aerial parts. Journal of Pharmacognosy and Phytotherapy., 2017, 9(11), pp. 165-172
19. Somnath De., Chandra D., Mandal T. In vitro anti-inflammatory and anti-diabetic activity of methanolic extract of Cardanthera difformis druce. International Research Journal Of Pharmacy., 2016, 7 (12), pp. 56-60
20. Twinkle S., Bansode B., Salalkar K. Exploiting the therapeutic potential of secondary metabolites from Salvadora persica for diabetes using in silico and in vitro approach. Journal of Life Science and Biotechnology., 2016, 5, pp. 127-136.
.jpg)
2.png)
