BAZI DORIVOR O’SIMLIKLARNING ANTIDIABETIK VA YALLIG’LANISHGA QARSHI FAOLLIKLARINI BAHOLASH
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Dorivor xususiyatlari noma'lum bo'lgan mahalliy o'simliklarning oshqozon osti bezi α-amilaza ingibitorlari sifatida foydalanish imkoniyatlari o'rganib chiqildi. Tanlab olingan 8 ta o’simliklar orasidan isiriq, moychechak va mavraklarni (mos ravshda 80%, 77% va 72%) etanol ekstraktlarining 100 mg/ml kontsentrasiyasi yuqori ingibitor faollikka ega ekanligi aniqlandi. Diabet kasalligini davolashda ishlatiladigan preparatlarning yallig’lanishga qarshi xususiyatining bo'lishi diabet bilan bog'liq asoratlarni kamaytirishda samarali vosita bo'lishi mumkinligi isbotlangan. Shunga ko'ra, isiriq, moychechak va mavrak o’simliklarining etanol ekstraktlari yallig’lanishga qarshi xususiyatlari o'rganildi. Ushbu o’simliklar ekstraktlari issiqlik bilan induktsiya qilingan qizil qon hujayralari membranasini barqarorlashtirdi. Bunda isiriq 82%, moychechak 79% va mavrak 85% yallig’lanishga qarshi faollikni ko'rsatdi. Shunga ko'ra bu o’simliklarning ekstraktlari 2-toifa diabetni davolashda istiqbollidir.
Iqbol MUXAMMEDOV, Muhayyoxon MAHAMMADJONOVA, Muxlisa ABDULATIBOVA, Sarvinoz TURDIMUHAMMADOVA, & Munisa MIRODILOVA. (2024). BAZI DORIVOR O’SIMLIKLARNING ANTIDIABETIK VA YALLIG’LANISHGA QARSHI FAOLLIKLARINI BAHOLASH. «O‘zMU XABARLARI», 3(3.1), 78–81. https://doi.org/10.69617/nuuz.v3i3.1.1717
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13. Sakat S, Juvekar AR, Gambhire MN. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. Int J Pharm Pharm Sci 2010;2:146-55.
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15. Sakat S, Juvekar AR, Gambhire MN. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. Int J Pharm Pharm Sci 2010;2:146-55.
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17. Selfayan M., Namjooyan F. Ingibitory effect of Capparis spinosa extract on pancreatic alpha-amylase activity. Zahedan J Res Med Sci., 2016; 18(4), pp. 1-4.
18. Sameer H., Nayer M. Evaluation of some biological activities of Trigonella hamosa aerial parts. Journal of Pharmacognosy and Phytotherapy., 2017, 9(11), pp. 165-172
19. Somnath De., Chandra D., Mandal T. In vitro anti-inflammatory and anti-diabetic activity of methanolic extract of Cardanthera difformis druce. International Research Journal Of Pharmacy., 2016, 7 (12), pp. 56-60
20. Twinkle S., Bansode B., Salalkar K. Exploiting the therapeutic potential of secondary metabolites from Salvadora persica for diabetes using in silico and in vitro approach. Journal of Life Science and Biotechnology., 2016, 5, pp. 127-136.
2. M. A. Bhutkar and S. B. Bhise. In vitro assay of alpha amylase ingibitory activity of some indigenous plants. Int. J. Chem. Sci.: 10(1), 2012, P. 457-462.
3. Mostafa Selfayan and Foroogh Namjooyan. Ingibitory effect of Capparis spinosa extract on pancreatic alpha-amylase activity. Zahedan J Res Med Sci. 2016; 18(4):e6450. P. 1-4
4. Marilyn L Barrett, Jay K Udani. A proprietary alpha-amylase ingibitor from white bean (Phaseolus vulgaris): A review of clinical studies on weight loss and glycemic control. Barrett and Udani Nutrition Journal 2011,10:24, P. 1-10.
5. Young-In Kwon, Emmanouil Apostolidis and Kalidas Shetty. Ingibitory potential of wine and tea against a-amylase and a-glucosidase for management of hyperglycemia linked to type 2 diabetes. Journal of Food Biochemistry 32 (2008) P. 15-31.
6. Twinkle S. Bansode and B. K. Salalkar. Exploiting the therapeutic potential of secondary metabolites from Salvadora persica for diabetes using in silico and in vitro approach. Journal of Life Science and Biotechnology ISSN: 2456-1061, 2016, 5, P. 127-136.
7. Ali S. Alqahtani, Syed Hidayathulla, Md Tabish Rehman, Ali A. ElGamal, Shaza Al-Massarani, Valentina Razmovski-Naumovski, Mohammed S. Alqahtani, Rabab A. El Dib and Mohamed F. AlAjmi. Alpha-amylase and alpha-glucosidase enzyme ingibition and antioxidant potential of 3-oxolupenal and katononic acid isolated from Nuxia oppositifolia. Biomolecules 2020, 10, 61; doi:10.3390/biom10010061, P. 1-19.
8. Gladis Raja Malar Chelladurai, Chellaram Chinnachamy. Alpha amylase and Alpha glucosidase ingibitory effects of aqueous stem extract of Salacia oblonga and its GC-MS analysis. Brazilian Journal of Pharmaceutical Sciences 2018;54(1):e17151 P. 1-10
9. Nidal Jaradat, Nawaf Al-Maharik. Fingerprinting, Antimicrobial, Antioxidant, Anticancer, Cyclooxygenase and Metabolic Enzymes Ingibitory Characteristic Evaluations of Stachys viticina Boiss. Essential Oil. Molecules 2019, 24, 3880, P. 1-14.
10. Agger J. W., Eijsink V. G. H., Horn S. J. On the Determination of Water Content in Biomass Processing. BioEnergy Research. 2014, 7(1) pp 442–449
11. Hazalin N.A., Ramasamy K., Lim S.M., Wahab I.A., Cole A.Lj., Majeed A.A. Cytotoxic and antibacterial activities of endophytic fungi isolated from plants at the National Park, Pahang, Malaysia. BMC Complementary and alternative medicine. 2009, 9, P. 46
12. Picot C.M.N., Subratty H., Mahomoodally F. Inhibitory potential of five native antidiabetic medicinal plants on α-amylase, α-glucosidase, glucose entrapment, and amylosysis kinetics in vitro. Adv. Pharm. Sci., 2014, pp. 1-7.
13. Sakat S, Juvekar AR, Gambhire MN. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. Int J Pharm Pharm Sci 2010;2:146-55.
14. Sadique J, Al-Rqobahs WA, Bughaith, EI Gindi AR. The bioactivity of certain medicinal plants on the stabilization of RBS membrane system. Fitoterapia 1989;60:525-32.
15. Sakat S, Juvekar AR, Gambhire MN. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. Int J Pharm Pharm Sci 2010;2:146-55.
16. Shinde UA, Kulkarni KR, Phadke AS, Nair AM, Mungantiwar AA, Dikshit VJ, et al. Mast cell stabilizing and lipoxygenase inhibitory activity of Cedrus deodara (Roxb.) loud. Wood oil. Indian J Exp Biol 1999;37:258-61
17. Selfayan M., Namjooyan F. Ingibitory effect of Capparis spinosa extract on pancreatic alpha-amylase activity. Zahedan J Res Med Sci., 2016; 18(4), pp. 1-4.
18. Sameer H., Nayer M. Evaluation of some biological activities of Trigonella hamosa aerial parts. Journal of Pharmacognosy and Phytotherapy., 2017, 9(11), pp. 165-172
19. Somnath De., Chandra D., Mandal T. In vitro anti-inflammatory and anti-diabetic activity of methanolic extract of Cardanthera difformis druce. International Research Journal Of Pharmacy., 2016, 7 (12), pp. 56-60
20. Twinkle S., Bansode B., Salalkar K. Exploiting the therapeutic potential of secondary metabolites from Salvadora persica for diabetes using in silico and in vitro approach. Journal of Life Science and Biotechnology., 2016, 5, pp. 127-136.
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