L-METIONINNI MIKROBIOLOGIK SINTEZI: METABOLIK MUHANDISLIKDAN SANOATGACHA BO‘LGAN YUTUQLAR VA MUAMMOLAR
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Ushbu maqolada L-metioninning mikrobiologik sintezi, uning biosintetik yo‘llari, regulyatsiya mexanizmlari va ishlab chiqarishdagi muammolar hamda ularni bartaraf etish bo‘yicha zamonaviy muhandislik yondashuvlari muhokama qilinadi. Ayniqsa, Corynebacterium glutamicum va Escherichia coli kabi model mikroorganizmlarda metionin ishlab chiqarishni kuchaytirishga qaratilgan genetik modifikatsiyalar, analoglarga chidamli mutantlar va tizimli metabolik muhandislik strategiyalarining roli yoritilgan. Homoserin oqimini tartibga solish, toksik metabolitlar oqibatlarini kamaytirish hamda metionin transport tizimlarini faollashtirish orqali fermentatsiya samaradorligini oshirish imkoniyatlari tahlil qilinadi.
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