МИКРОБИОЛОГИЧЕСКИЙ СИНТЕЗ L-МЕТИОНИНА: ДОСТИЖЕНИЯ И ПРОБЛЕМЫ ОТ МЕТАБОЛИЧЕСКОЙ ИНЖЕНЕРИИ ДО ПРОМЫШЛЕННОГО УРОВНЯ
В данной статье рассматриваются микробиологический синтез L-метионина, его биосинтетические пути, механизмы регуляции, производственные проблемы и современные инженерные подходы к их решению. Особое внимание уделено генетическим модификациям модельных микроорганизмов, таких как Corynebacterium glutamicum и Escherichia coli, устойчивости к аналогам метионина и применению системной метаболической инженерии. Также анализируются пути повышения эффективности ферментации за счёт регулирования потока гомосерина, снижения токсичности промежуточных метаболитов и оптимизации транспортных систем метионина.
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