ALOE VERA O’SIMLIGIDAN AJRATIB OLINGAN ENDOFIT ZAMBURUG’LARINING FITOKIMYOVIY TAHLILI VA UREAZA INGIBIRLOVCHI FAOLIYATI
##submission.downloads##
Ushbu tadqiqotda Aloe vera o'simligidan ajratib olingan 13 ta endofit zamburug'larning ureazani ingibirlovchi faolligi tekshirildi. Aloe vera o'simligining AV5L (88,1%), AV6L (88,0%), AV4L (60%) va AV8R (63%) endofit izolatlarining ekstraktlarini o'rganish va ularning ureazaga nisbatan yuqori ingibitorlik faolligi ko'rsatildi. Taqqoslash uchun, Aloe vera barglari ekstrakti o'rtacha ingibitorlik faolligni ko'rsatdi (50%). Standart ureaza ingibitori tiokarbamid eng yuqori ingibitorlik darajasini ko'rsatdi (94%).
Ushbu birikmalar sinflarining mavjudligi ushbu shtammlarning ureazani ingibirlash uchun ma’sul bo'lgan biologik faol moddalar manbai sifatida potensialini ko'rsatadi. Olingan natijalar tabiiy kelib chiqishi samarali ureaza ingibitorlari manbalari sifatida muhim salohiyatga ega bo'lgan Aloe vera endofit izolatlaridan foydalanish istiqbollarini tasdiqlaydi.
1. Anuradha Balasubramanian, Karthe Ponnuraj. Crystal structure of the first plant urease from jack bean: 83 years of journey from its first crystal to molecular structure.Mol.Biol.2010Jul16;400(3):274-83. doi:0.1016/j.jmb. 2010.05.009. Epub 2010 May 13.
2. A.E, Ajadi, A.K.Ajijolakewu, T.A.Sorunke, M.M.Suleiman, S.AAyoola and O.O Abdulai. Therapeutic Potential of Secondary Metabolities from Endophytic Fungi in Biotechnology and Medicine. Nig.J.Pure and Appl.Sci.Vol. 37 (Issue 1,2024) e-ISSN 2756-4045
3. Alvarez, M., et al. (2018). Peptides as Urease Inhibitors: Current Progress and Future Directions. Peptide Science, 108(4), 1-7. DOI: 10.1002/peps.23721
4. Dominika Matczuk, Anna Siczek. Effectiveness of the use of urease inhibitors in agriculture: a review/ International Agrophysics, 2021,35,197-208.
5. Iwona Koniecznal, Paulina Arnowiec, Marec Kwinkowski, Beata Kolesinska, Jastuna Fraczyk, Zbigniew Kaminski and Wieslaw Kaca. Bacterial Ureasa and its role in long lasting human diseases. Current protein and peptide science, 2012, vol13, No.8
6. J.P.Zhang, L.X.Chen, H. B.Lu,W.T. Lin "Urease Inhibitory Activity of Alkaloids from Fusarium and Aspergillus Endophytic Fungi" Phytochemistry.Volume:75,Issue:4,P.87-94,Year: 2017.
7. Ibrahim Kahramonoglu, Chuying Chen, Jinyin Chen and Chunpeng Wan. Chemical Constituents, Antimicrobial Activity, and Food Preservative Characteristics of Aloe vera Gel. Agronomy 2019, 9 (12), https://doi.org/10.3390/agronomy9120831
8. Rahul Yadav,Ajay Veer Singn, Samiksha Joshi and Manish Kumar. Antifungal and enzyme activity of endophytic fungi isolated from Ocimum and Aloe vera. Africa journal of Microbiology research. Vol.9(29), 2015.
9. Bhagobaty, R.K., & Joshi, S.R. (2011). Antimicrobial activity of endophytic fungi isolated from Centella asiatica and Aloe vera. International Journal of Pharmaceutical Sciences and Research, 2(3), 104–109.
10. Strobel G, Yang X, Sears J, Kramer R, Sidhu R.S., and Hess W. M., “Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana,” Microbiology (Reading), vol. 142 (Pt 2), pp. 435–440, Feb. 1996, doi: 10.1099/13500872-142-2-435.
11. Wang, X., Min, C., Ge, M., & Zuo, R. (2013). An Endophytic Sanguinarine-Producing Fungus from Macleaya cordata, Fusarium proliferatum BLH51. Current Microbiology, 68(3), 336–341. https://doi.org/10.1007/s00284-013-0482-7.
12. Hazalin N.A., Ramasamy K., Lim S.M., Wahab I.A., Cole A.Lj, Majeed A.A.: Cytotoxic and antibacterial activities of endophytic fungi isolated from plants at the National Park, Pahang, Malaysia. BMC Complementary and alternative medicine. 2009, 9:46.
13. Prabhavathi RM, Prasad MP, Jayaramu M. Studies on Qualitative and Quantitative Phytochemical Analysis of Cissus quadrangularis. Adv Appl Sci Res 2016; 7:11-17.
14. Weatherburn M.W. (1967). Phenol-Hypochlorite Reaction for Determination of Ammonia. Analytical Chemistry, 39(8),971-974.
15. Seyedan, A., et al. (2019). Flavonoids as Natural Urease Inhibitors: A Review of Mechanisms and Therapeutic Potential. Journal of Enzyme Inhibition and Medicinal Chemistry, 34(1), 1-13. DOI: 10.1080/14756366.2019.1582493.
16. Shabnam Mahernia, Kowsar Bagherzadeh, Faraz Mojab and Massoud Amanlou. Ureasa Inhibitory Activities of some Commonly Consumed Herbal Medicines. Iranian Journal of Pharmaceutical Research, January 2014.
17. Shokrzadeh, M., et al. (2021). Tannins as Urease Inhibitors: A Review on Their Mechanisms and Therapeutic Potential. Phytotherapy Research, 35(2), 389-404. DOI: 10.1002/ptr.6785
18. Shokrzadeh, M., et al. (2021). Tannins as Urease Inhibitors: A Review on Their Mechanisms and Therapeutic Potential. Phytotherapy Research, 35(2), 389-404. DOI: 10.1002/ptr.6785
Mulkiiyat (c) 2025 «O‘zMU XABARLARI»

Ushbu ish quyidagi litsenziya asosida ruxsatlangan Kreativ Commons Attribution-NonCommercial-ShareAlike 4.0 International litsenziyasi asosida bu ish ruxsatlangan..






.jpg)

.png)





