35, AD-3, GS4/2, EB-2, AK-42, AG-1,5, 17, 16 SUBSTANSIYALARINING IMMUNOTROP FAOLLIGINI ANIQLASH BO‘YICHA SKRINING TADQIQOTLARI
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Ushbu tadqiqotda 35, AD-3, GS4/2, EB-2, AK-42, AG1,5, 17 va 16 8 ta yangi kimyoviy substansiyalarning immunotrop faolligi sichqonlarda in vivo sharoitida baholandi. Substansiyalar bir marta peroral kiritilib, 48 soatdan so‘ng immun tizimi organlari - timus, qora taloq va qo‘ltiq osti limfa tugunlaridagi yadro tutuvchi hujayralar (YaH) hamda qorin bo‘shlig‘i peritonial suyuqligidagi makrofaglar soniga ta’siri aniqlandi. Tadqiqot natijalari AD-3, GS4/2, EB-2 va AK-42 substansiyalari makrofaglar sonini oshirish orqali fagotsitar faollikni rag‘batlantirishini ko‘rsatdi (RI=1,6–3,04). Timus va periferik immun organlar tahlili GS4/2, AG1,5 va 17 substansiyalari T-hujayraviy immunitetni faollashtirish xususiyatiga ega ekanligini tasdiqladi. Qiyosiy tahlilga ko‘ra GS4/2, AG1,5 va 17 yuqori immunotrop faollikka, 35, AD-3 va EB-2 o‘rtacha faollikka, AK-42 va 16 esa sezilarli faollikka ega emasligi aniqlandi.
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