FLAVONOIDLARNING EKSPERIMENTAL DIABET SHAROITIDA GLYUKOZANING METABOLIK REGULYATSIYASI VA α-AMILAZA FAOLLIGIGA TA’SIRI
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Ushbu tadqiqot ishida alloksan yordamida chaqirilgan eksperimental qandli diabet sharoitida flavonoidlar - kversetin va
digidrokversetinning uglevod almashinuvi ko‘rsatkichlariga ta’siri o‘rganildi. Tajribada 150-180 g tana vazniga ega Wistar zotli
kalamushlarda diabet modeli yaratildi. 14 kun davomida 25 mg/kg dozada peroral yuborilgan flavonoidlarning qondagi glyukoza,
α-amilaza va albumin ko‘rsatkichlariga ta’siri baholandi. Natijalar flavonoidlar qo‘llanilishi fonida giperglikemiya, α-amilaza
faolligi va giperalbuminemiya sezilarli darajada kamayganini ko‘rsatdi. Olingan ma’lumotlar kversetin va digidrokversetinning
gipoglikemik, antioksidant va metabolik korreksiyalovchi xususiyatlarga ega ekanligini hamda diabet patogenezida istiqbolli
vosita bo‘lishi mumkinligini tasdiqlaydi.
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